Esterification of p-hydroxybenzoic acid with glucose using a γ-Al2O3/SO4 catalyst

Authors

  • Elfia Siska yasa Putri Universitas Muhammadiyah Prof.DR.Hamka
  • Widajanti Wibowo Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok
  • Soleh Kosela Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Indonesia, Depok

DOI:

https://doi.org/10.12928/pharmaciana.v9i1.11892

Keywords:

esterification, p-hydroxybenzoic acid, glucose, SO42-/Al2O3 catalyst

Abstract

Esterification of p-hydroxybenzoic acid with glucose can be expected to produce esters. The rate of esterification reaction is usually very slow and, therefore, needs an acid catalyst to accelerate it. This research examined the performance of a heterogeneous catalyst made of γ-Al2O3 impregnated with a protic acid, H2SO4. The heterogeneous catalyst, γ-Al2O3/SO4, was characterized using XRD, XRF, and BET methods. The esterification reactions were conducted using dimethyl sulfoxide (DMSO) solvent at a temperature of 1000C and observed after they lasted for 1 to 24 hours (reaction time). The esterification of p-hydroxybenzoic acid with glucose used two catalysts, namely 3% SO42-/Al2O3 and 5% SO42-/Al2O3. The reaction products were analyzed using HPLC, IR, and LC-MS methods. The % yield was the highest at Hour 24 for both catalysts, while the % conversion fluctuated during the esterification time. The LC-MS showed that the three produced esters had molecular weights of 300, 420, and 540.

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Published

2019-05-23

Issue

Vol. 9 No. 1 (2019): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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