The formulation of carvedilol transdermal patch with resin gum as rate control

Kori Yati, Septiana Tri Pamungkas


Carvedilol is widely prescribed for long-term hypertension treatment. It is rapidly absorbable by oral administration, but its bioavailability is merely about 20% in humans. Drug delivery is therefore imperative to overcome this weakness. One form of transdermal drug delivery system is a patch. Transdermal patch is composed of various systems, for instance, a reservoir that uses a rate control layer to manage the rate of drug release. This research aimed to observe the effect of using resin gum as the control of drug release rate on the physical characteristics and release of carvedilol in a transdermal patch. The patches were prepared in 5 formulas with different quantities of resin gum, namely 50, 100, 150, 200, and 250 mg. Afterward, they were evaluated physically, and their dissolution and diffusion rates were analyzed. The results showed that resin gum with concentrations of 150 mg and 200 mg was physically qualified for rate control. Besides, the results of dissolution and diffusion tests revealed that transdermal patches with 150 mg of resin gum exhibited the best drug release and penetration.


carvedilol, rate control, reservoir, resin gum, transdermal patch

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Ahad, A., Al-Jenoobi, F., Al-Mohizea, A.M., Akhtar, N., Raish, M., & Aqil, M., 2014, Systemic Delivery of β-blockers via Transdermal Route for Hypertension, Saudi Pharmaceutical Journal.

Alexander, A., Dwivedi, S., Ajazuddin, Giri T.K., Saraf, S., & Tripathi D.K., 2012, Approaches for Breaking the Barriers of Drug Permeation Through Transdermal Drug Delivery, Journal of Controlled Release, 164(1), 26–40.

Coppen J.J.W., 1995, Non-Wood Forest Products 6 : Gums, Resins and Latexes of Plant Origin. Food and Agriculture Organization of The United Nations, Rome, 65.

Mundada A.S., & Avari J.G., 2009, Permeability studies of Damar Batu Free Films for Transdermal Application, Chemical Industry and Chemical Engineering Quarterly, 15(2), 83–88.

Patel H., Bhimani B., & Patel G., 2012, Transdermal Drug Delivery System As Prominent Dosage Forms for the Highly Lipophilic Drugs, International Journal of Pharmaceutical Bio-Science, 1(3), 42–65.

Premjeet S., Bilandi A., Sahil K., & Akanksha M., 2011, Transdermal Drug Delivery System (Patches ), Applications In Present Scenario, International Journal Of Research In Pharmacy And Chemistry, 1(4), 1139–1151.

Saroha K., Yadav B., Sharma B., 2011, Transdermal Patch : A Discrete Dosage Form. International, Journal of Current Pharmaceutical Research, 3(3), 98-108.

Sonjoy M., Thimmasetty, Ratan & Kilarimath, 2011, Formulation and Evaluation of Carvedilol Transdermal Patches, International Research Journal of Pharmacy, 2(1), 237-248.



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ISSN Print: 2088-4559 | ISSN Online: 2477-0256
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