KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010

Authors

  • Siti Rahmiati Fakultas Farmasi UAD
  • Woro Supadmi Fakultas Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v2i1.658

Keywords:

drug interactions, antihypertensive, hemodialysis

Abstract

Drug interactions are one of the Drug Related Problems (DRPs) that may affect
patient treatment outcomes. Hypertension occurs in approximately 10% to 81.5% of
hemodialysis patients. The purpose of this study was to determine the incidence of
antihypertensive drug interactions in hemodialysis patients in the inpatient wards PKU
Muhammadiyah Hospital of Yogyakarta period in 2010. This study descriptive design.
Data retrieved retrospectively. Data retrieval were done by taking all the data that
meet the criteria of existing research on the medical records of hemodialysis patients in
PKU Muhammadiyah Hospital of Yogyakarta who received antihypertensive with
above normal blood pressure (= 130/80 mmHg). Data were analyzed based on the
descriptive level of significance, onset, and severity. The results showed that there were
54.79% (40 patients) of 73 hemodialysis patients potentially experienced drug
interactions. Antihypertensive drugs most widely used in hemodialysis patients were
ACEI, CCB, and diuretics. Incidence of antihypertensive drug interactions 27 cases
(45.76% were most common at a significance level 3, 48 cases (81.36%) were onset
delayed, and the severity minor of 44 cases (74.58%). The mechanism of interactions
pharmacodynamic were 37 cases (62.71%) of the total 59 events that have drug
interactions. Drugs often interactions were furosemide and captopril.

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Published

2012-05-01

Issue

Vol. 2 No. 1 (2012): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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