SINTESIS TURUNAN ASETOFENON DARI 1-(4-ASETOKSIFENIL-3-METOKSI)-2-PROPANIL FORMAT

Authors

  • Kusmiyati Kusmiyati Fakultas Farmasi UAD
  • Sabirin Matsjeh Fakultas MIPA UGM
  • Jumina Jumina Fakultas MIPA UGM

DOI:

https://doi.org/10.12928/pharmaciana.v2i1.654

Keywords:

Fries rearrangement, 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate, 1-(2-hyidroxy-3-methoxy-5-propenyl)-acetophenone

Abstract

The Synthesis of acetophenone derivative from 1-(4-acetoxyphenyl-
3-methoxy)-2-propanyl formate through Fries Rearrangement in order to produce
ortho hidroxy acetophenone derivative as starting material of Flavanoid compound has
been done. The reaction of 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate was
done by heating at 120 °C for 3 hours under AlCl3, dichloromethane as the catalyst and
solvent, respectively. The structure of the compound was identified using Infra Red
spectrometry (IR) dan GC-MS. Fries rearrangement of 1-(4-acetoxyphenil-3-
methoxy)-2-propanyl formate produce 1-(2-hyidroxy-3-methoxy-5-propenyl)-
acetophenone and 1-(2-hyidroxy-3-methoxy-5-propanyl)-acetophenone as side
product with product rendemen were 43.26% and 9.48%, respectively.

Downloads

Published

2012-05-01

Issue

Vol. 2 No. 1 (2012): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

License

Authors who publish with Pharmaciana agree to the following terms:

  1. Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.