OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (DC) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN

Authors

  • Endah Nurlaela Fakultas Farmasi UAD
  • Nining Sugihartini Fakultas Farmasi UAD
  • Azis Ikhsanudin Fakultas Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v2i1.652

Keywords:

Aedes aegypti female, repellent, sere volatile oil (Cymbopogon citratus (D.C) Stapf), emulgator, Simplex Lattice Design, Vanishing Cream

Abstract

The disease of Dengue hemorrhagic fever (DHF) is caused by the bite of female
Aedes aegypti mosquito. Cream of repelan sere leaf essential oils can be used to prevent
mosquito bites. The cream of volatile oil sere (Cymbopogon citratus (DC) Stapf)
required emulsifier to maintain the stability of cream. Tween 80 and Span 80 is a widely
used emulsifier in a cream formula. Aims of this study is to determine the optimum
composition of Tween 80 and Span 80 as emulsifier in a cream repelan of sere leaf
essential oils in the basis Vanishing Cream with Simplex Lattice Design methode. Three
Formula cream is designed based on the Simplex Lattice Design methode with a ratio of
Tween 80: Span 80 as follows: FI (100%-0%), F II (50%-50%), F III (0%-100%).
Cream was then tested repelan activity and physical properties that include
spreadibility, adhesivity and irritation. Data of physical properties and repellant
activity was calculate to get the optimum formula. The validity of optimization methods
was evaluated by comparing experimental results with predicted results in optimum
cream formula with t test at 95% level of confidence. The results of study showed that the
optimum composition of Tween 80: Span 80 was 60%:40%. Cream with optimum
emulsifier composition was predicted has spreadibility 29.24 cm2; adhesivity 3.512
seconds; irritation 0.608; power repelan 41.469 minutes. T test results showed no
significant differences between the experimental results and predicted results (p
<0.05).

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Published

2012-05-01

Issue

Vol. 2 No. 1 (2012): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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