ANALISIS SGPT-SGOT EKSTRAK ETANOL DAGING BUAH PARE (Momordica charantia L.) PADA TIKUS JANTAN PUTIH GALUR WISTAR

Authors

  • Dwi Ari Nugrahani Fakultas Farmasi UAD
  • Vivi Sofia Fakultas Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v1i2.523

Keywords:

bitter melon fruit, toxicity, blood chemistry

Abstract

The traditional medicine in Indonesia which is the cultural heritage and has
become an integral part of the life of the nation Indonesia, want to be employed in the
formal health care system. As the circulation of drugs in general terms, traditional
medicine should fulfill the requirements of quality, safe, and efficacious. This study
aims to analyze the levels of SGPT, SGOT of suspension of the ethanol extract of bitter
melon fruit (Momordica charantia L.) by orally. The study was conducted using a white
male Wistar rats amounted to 36 animals, divided into 6 groups. Each group consisted
of 6 male white rats. Group I (control) were given 0.5% CMC solution of 2.5 ml/200 g
BW. Group II was given a suspension dosage doses of bitter melon fruit extract ethanol
0.5 g/kg, then consecutive group III with the test preparation doses of 1 g/kg, the test
preparation group IV were given a dose of 2 g/kg, group V was given dosage test dose
of 4 g/kg, and group VI were given the highest dose of the test preparation 8 g/kg. The
results of acute toxicity tests on white male Wistar rats showed that administration of
ethanol extract of peroral dosage suspension pare (Momordica charantia L.) single
dose on white male Wistar rats from the dose of 0.5 g/kg until a dose of 8 g/kg did not
significantly influence the value of SGPT, SGOT.

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Published

2011-11-01

Issue

Vol. 1 No. 2 (2011): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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