FORMULASI VANISHING CREAM MINYAK ATSIRI SERE (Cymbopogon citratus (DC) Stapf) DAN UJI SIFAT FISIKNYA SERTA UJI AKTIVITAS REPELAN TERHADAP NYAMUK Aedes aegypti BETINA

Authors

  • Azis Ikhsanudin Fakultas Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v1i1.518

Keywords:

Vanishing Cream, Repellant, sere essential oil (Cymbopogon citratus (DC) Stapf.), female Aedes aegypti mosquitoes

Abstract

Essential oil of sere leaf has been proven as repellant against mosquitoes. This research aims to know about the influence of concentration sere essential oil (Cymbopogon citratus (DC) Stapf) in a vanishing cream bases to physical properties and repellant testing against female Aedes aegypti mosquitoes. Essential oil of sere (Cymbopogon citratus (DC) Stapf) was isolated with steam water distillation and was evaluated the organoleptic appearance and refraction index. Furthermore, the essential oils were formulated in a vanishing cream base with the different formulas, contain formula I: 20% v/w; formula II: 30% v/ w and formula III: 40% v / w. Then this three formulas were evaluated for physical properties including adhesive, dispersive and the repellent activity testing against female Aedes aegypti mosquitoes amount of twenty mosquitoes per cage while seven female volunteers as the probandus. The data have been analyzed using Kolmogorov-Smirnov test and t-test (Main-Whitney), with 95% signifancy level. The results were obtained that the adhesion of formula I: 0.90 ± 0.029 seconds, formula II: 0.60 ± 0.017 seconds, formula III: 0.46 ± 0.040 seconds, while the dispersion of formula I is 64.89 ± 4.559 cm2 , the formula II is 64.71 ± 4.600 cm2 and the formula III is 54.96 ± 14.783 cm2 . The longest time repellent was formula III showed 3014.2 ± 20.163 seconds or 50.23 minutes. It was concluded that the increase of concentration essential oils of sere leaf followed by the increase of repellant activity.

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Published

2011-05-01

Issue

Vol. 1 No. 1 (2011): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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