EFEK EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) TERHADAP MEMORI SPASIAL TIKUS MODEL DEMENSIA YANG DIINDUKSI TRIMETHYLTIN

Authors

  • Nuroh Aspamufita Farmasi UAD
  • Sapto Yuliani Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v3i2.432

Keywords:

Curcuma xanthorrhiza Roxb, spatial memory, Morris water maze

Abstract

Curcuma xanthorrhiza Roxb is one of the plants containing curcumin. Curcumin has anti-amyloidogenic,
antioxidant, and anti-inflammatory activity that can prevent dementia. The aim of the research was to know the
effect of Curcuma xanthorrhiza Roxb rhizome ethanol extract (CREE) to spatial memory on dementia model rat
induced by trimethyltin (TMT). This research use 30 rats, divided into 6 groups, each group consisted of 5 rats. All
groupswere given trimethyltin intraperitoneal lyexcep tgroup I.Group I (healthy controls) and group II (TMT
/illness control) were given a solution of 1% CMC-Na orally. Group III (drug control) were given citicoline 200
mg/kgBW orally. Group IV, V, and VI were given CREE orally dose 50 mg/kgBW, 100 mg/kgBW, and 150
mg/kgBW respectively. Data of spatial memory were obtained by Morris water maze test consisted of acquisition
trial, and a probe trial. Data from the test then statistically analyzed by one-way repeated measure ANOVA.
Morris water maze test showed that there were significant differences (p<0,05) between TMT group compared
with CREE dose 50 mg/kgBW, 100 mg/kgBW, and 150 mg/kgBW group. But there was no significant difference
(p>0,05) between CREE dose100 mg/kgBW group anddrug control group.Based on the research results can be
concluded that ethanol extract Curcuma xanthorrhiza Roxb rhizome at dose of 100 mg/kgBW can improve
spatial memory on dementia model rat induced by trimethyltin.

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Published

2013-11-01

Issue

Vol. 3 No. 2 (2013): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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