DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL

Authors

  • Resty Annisa Damayanti Farmasi UAD
  • Tedjo Yuwono Farmasi UAD

DOI:

https://doi.org/10.12928/pharmaciana.v3i1.419

Keywords:

DMSO, enhancer, theophylline

Abstract

Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. This
substance is used as a medicine and solve. It can also be used as an absorption
enhancer of various drugs, either synthetical or herbal medicines. This study conducted
with DMSO as transdermal absorption enhancer of theophylline, which often used as
an anti-cellulite dosage forms. The experiments studied in vitro transdermal
absorption of theophylline in gel dosage forms, containing 7% theophylline dan
various concentration of DMSO i.e. 0% , 3%, 5% and 7% DMSO respectively. These
studies used skin membrane of Wistar strain male rats in a vertical type diffusion Cell.
The results indicated that DMSO was very potential as a permeation enhancer
theophylline, the formula containing 7% DMSO increased the theophylline transport
from 17,9 µg to 139,1 µg.

Downloads

Issue

Vol. 3 No. 1 (2013): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

License

Authors who publish with Pharmaciana agree to the following terms:

  1. Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.