PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 µg DAN 100 µg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA

Authors

  • Haafizah Dania Farmasi UAD
  • Djoko Wahyono Farmasi UGM
  • Sulistiari Retnowati Bagian Obstetri Ginekology RSU PKU Muhammadiyah Yogyakarta

DOI:

https://doi.org/10.12928/pharmaciana.v4i1.401

Keywords:

induction success, misoprostol 50 µg, misoprostol 100 µg

Abstract

In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripening
at pregnancy and labor induction. However, until now misoprostol dosage and administration route for
induction are various. There is no fix guide on administration and dosage of misoprostol. This research
was intended to identify profile of misoprostol usage and effectiveness of misoprostol administration
at dosage of 50 µg and 100 µg on labor process progress of patient hospitalized in Yogyakarta PKU
Muhammadiyah Hospital based on induction success. This research was non experimental research
with historical cohort design. Limitation of this method was not all desired data exist in medical record
and capability of physician was not same. Subject was pregnant mothers giving birth with misoprostol
induction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009
to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptively
analytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administration
at 50 µg and 100 µg dosage on labor process progress. Research subjects who meet the inclusion
criteria in this research was 109 mothers, where 69 women (63,30%) got 50 µg misoprostol and 40
women (36,70%) got 100 µg misoprostol. The results of this study indicate that the success of
induction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR
= 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%),
while the success induction at 100 ug misoprostol group as many as 39 people from 40 people
(97.50%). The difference was statistically significant with p = 0.014 (p <0.05).

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Published

2014-05-01

Issue

Vol. 4 No. 1 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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