SINTESIS 4–HIDROKSI–3–KLOROBENZALDEHID DARI p–HIDROKSIBENZALDEHID DAN GAS Cl2

Authors

  • Warsi Warsi

DOI:

https://doi.org/10.12928/pharmaciana.v5i1.2967

Keywords:

3–chloro–4–hydroxybenzaldehyde, chlorination, halogenation

Abstract

Curcumin is a compound which potential to be developed. The curcumin analogues have
been synthesized. The compound 3–chloro–4–hydroxybenzaldehyde was used as starting material in
the synthesis of curcumin analogues with Cl substituent on the aromatic ring. The compound of
3–chloro–4–hydroxybenzaldehyde were synthesized by chlorination reaction between
p–hydroxybenzaldehyde and Cl2 gas. The purity of 3–chloro–4–hydroxybenzaldehyde was
determined base on the melting range, thin layer chromatography and LC–MS. The structure
identification of the compound was observed done by spectrometry techniques, including mass
spectra (ESI–MS), infrared spectra (cm-1, KBr), Nuclear Magnetic resonance proton spectra (δ, ppm,
DMSO-d6, 1H–NMR, 500 MHz) and UV–Vis spectra. Chlorination reaction of
p–hydroxybenzaldehyde produced yellow crystal of 3–chloro–4–hydroxybenzaldehyde, its melting
range is 128.1 to 130.8ºC. The average yield obtained of this reseach is 51.37%.

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Issue

Vol. 5 No. 1 (2015): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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