Study of adverse effects of extrapyramidal syndrome use of combination of antipsychotics antidepressants in outpatient schizophrenia patients in RSUP Fatmawati for the period 2016-2020
DOI:
https://doi.org/10.12928/pharmaciana.v13i2.23280Keywords:
Schizophrenia, antipsychotics, antidepressants, extrapyramidal adverse effectsAbstract
Schizophrenia disorder is a serious mental disorder and chronic symptoms that have mixed of schizophrenia and mood symptoms. Schizophrenia affects the individual concerned. Schizophrenia has several symptoms that can cause social and occupational dysfunction, such as disruption of work or activities, lack of interpersonal relationships, decreased self-care skills, and mortality. This study was an observational study with a cross-sectional study design using secondary data in the form of medical records. The population of this study is 449 patients, and 126 patients met the inclusion criteria. The number of patients with age 20-35 years is 47.6%, 54% male gender, 96.8% take the drug by oral. The most common diagnosis of the patient with schizophrenia was paranoid schizophrenia 100 (79.4%), and got the most common extrapyramidal adverse effect in acute dystonia is 32.5%. The type of drug that may cause extrapyramidal adverse effects are the Risperidone antipsychotic in 90 (17.9%). The results of the study showed that there was no significant relationship between the type of drug combination use and the incidence of adverse effects from extrapyramidal syndrome with a sig. 0.966> 0.05. Meanwhile, the number of drugs consumed by the patients did not have a significant relationship with the sig value. 0.119> 0.05. The Gender, patient age, method of administration, and diagnosis of schizophrenia did not affect the adverse effects of extrapyramidal syndrome with sig values of each gender (p=0.881), patient age (p=0.665), method of administration (p=0.920), and diagnosis of schizophrenia (p=0.908).
References
Atika, Wahyu., Loranda, Angeline. 2018. Analisis potensi interaksi obat golongan antidepresan pada pasien skizofrenia dirumah sakit jiwa Dr. Soeharto Heerdjan tahun 2016. Depok. Fakultas Farmasi : Univeritas Indonesia.
Bruno, V., Valiente, Gumez., Alcoverro, O., 2015. Clozapine and fever a case of continaed therapy with clozapine. Clinical neuropharmacology. 38(4). 151-153.
Burkhard, PR. Acute and subacute drug-induced movement disorders. Park relat disord. 2014:20.
Dharmono, S. 2011. Konsensus penatalaksanaan gangguan skizofrenia. Jakarta : Perhitungan dokter spesialis kedokteran jiwa indonesia.
Divac, N., prostram, M., Jakovcevski., cerovac. Second-generation antipsychotic and ekstrapiramidal adverse effects. BioMed research internasional. 2014; 2014:1-6.
Emsley, R., Chiliza, B., Asmal, L., Harvey, B. 2013. The nature of relaps in schizophrenia. BMC Psychiatric, 13.
Fahrul., Mukaddas, Alwiyah., Faustine, I. 2014. Rasionalitas penggunaan antipsikotik pada pasien skizofrenia diinstalasi rawati inap jiwa RSD Medan Provinsi Sulawesi Tengah periode Januari-April 2014. Online Jurnal of Natural Science, Vol.3(2) : 18-29.
Jesica, Tarigas., Eka, Kartika., Nurmainah. 2018. Analsysis the potential for serotonin synrome in the use of antidepressant drugs to schizophrenic parients in psychiatric hospital in the Sungai Bangkong Pontianak periode January-December 2018. Pharmacy Departemen Medical, Tanjungpura University : Pontianak.
Kaunang, I., Kanine, E., Kallo, V. 2015. Hubungan kepatuhan minum obat dengan prevalensi kekambuhan pada pasien skizofrenia yang berobat jalan di ruang poliklinik jiwa rumah sakit Prof Dr. VL Ratumbuysang Manado. Jurnal Keperawatan 3(2).
Natari, R.B., Sukandar, EY., Sigit, SI. Antipsychotic use evaluation on first episode schizophrenic patients at jambi psychiatric hospital. XXXVII, 159-165 (2012)
Notoatmodjo, S. 2010. Metodologi Penelitian Kesehatan. Jakarta : Rineka Cipta.
Redayani dkk. 2015. Buku ajar psikiatri Edisi ke 2. Jakarta. Balai Penerbit Fakultas Kedokteran : Universitas Indonesia.
Rianti, I., Oktaviany, A.F., Kinanti, S. 2015. Analisis efektivitas terapi dan biaya antara haloperidol kombinasi dnegan riseperidon kombinasi pada terapi skizofrenia fase akut. Yogyakarta : Universitas Muhammdiyah Yogyakarta.
Staurt, GW., Laraia. 2005. Principles and practice of psychiatric mursing. Philadelphina : Elservier mosby, alih bahasa budi santosa.
Teter, et al. 2015. Depressive disorder, in Dipiro (eds) : Pharmacotherapy, a pathophysiological approach,7th ed, McGraw Hill, New York,p:1101 The International Statistical Classification of Diseases (ICD-10).
Tjay dan Raharja. 2002. Obat-obat penting khasiat, penggunaan dan efek-efek sampingnya. PT Elex Media Komputindo Kelompok Kompas-Gramedia. Jakarta : 262-269.
Tjay., Rahardja. 2017. Obat-obat penting. Elex media komputindo. Jakarta.
Wijono, R., M., Nasrul, C, E, Damping. 2013. Gambaran dan karakteristik penggunaan trihexyfenidil pada pasien yang mendapat terapi antipsikotik. Departemen psikiatri fakultas kedokertan univeristas indonesia, rumah sakit cipto mangunkusumo. Jakarta.
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