The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system

Authors

  • Beti Pudyastuti Departement of pharmacy, jenderal soedirman university
  • Triyadi Hendra Wijaya departement of pharmacy, jenderal soedirman university

DOI:

https://doi.org/10.12928/pharmaciana.v12i3.18881

Keywords:

Kencur rhizome ethanol extract, SNEDDS, surfactant, nanoemulsion

Abstract

Kencur (Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility of the extract in water. The purpose of this study was to determine the effect of surfactant combination on the kencur rhizome extract in the SNEDDS system. The SNEDDS formulations were carried out by selecting the surfactant ratio of Tween 80:Span 80 and Tween 80:Chremophor RH 40, followed by selecting the ratio of surfactant mixtures to polyethylene glycol 400 as co-surfactant, and to virgin coconut oil as the oil phase. The clarity, transmittance, emulsification time, particle size, and polydispersity index were evaluated. The stability test was carried out in aquadest, artificial gastric fluid, and artificial intestinal fluid for 4 hours at 37°C. The results showed that the combination of Tween 80: Chremophor RH 40 produced better SNEDDS than Tween 80:Span 80. The combination of surfactant-cosurfactant of Tween 80:Chremophor RH 40:PEG 400 at ratio 3:1 and 1:1 could produce homogenous dispersed SNEDDS showing droplet size of 23,0 and 21,8 nm; transmittance of 95.63% and 93.83%, and SNEDDS preconcentrate emulsified less than 35 seconds. The single surfactant Tween 80:PEG 400 at the ratio 3:1 produce better dispersed SNEDDS than the combined surfactant with droplet size 16.3 nm, transmittance 97.85%, and SNEDDS preconcentrate emulsified less than 45 seconds. The SNEDDS system could produce a smaller droplet size than the extract in aquadest.

Author Biographies

Beti Pudyastuti, Departement of pharmacy, jenderal soedirman university

Departement of Pharmaceutical Technology

Triyadi Hendra Wijaya, departement of pharmacy, jenderal soedirman university

Departement of Pharmaceutical Analysis

References

Balakumar K., Raghavan, C.V., Selvan, N.T., Prasad, R.H., & Abdu, S., 2013, Self Nanoemulsifying Drug Delivery System (SNEDDS) of Rosuvastatin Calcium: Design, Formulation, Bioavailability and Pharmacokinetic Evaluation, Colloids and Surfaces B: Biointerfaces, 112: 337-343.

Basalious, E.B., Shawky, N., & Badr-Eldin, S.M, 2010, SNEDDS containing Bioenhancers for Improvement of Dissolution and Oral Absorption of Lacidipine: Development and Optimization, Int. J. of Pharmaceutics, 391(1-2), 203-211.

Chen, H., Khemtong, C., Yang, X., Chang, X., & Gao, J., 2011. Nanonization strategies for poorly water-soluble drugs. Drug Discov. Today 16, 354–360.

Chinwong, S, Chinwong, D, & Mangklabruks, A, 2012. The Effect of Daily Consumption of Virgin Coconut Oil on Plasma Lipoproteins Levels in Healthy Thai Volunteers, Geneva Health Forum

Date, A.A., Desai, N., Dixit, R., & Nagarsenker, M., 2010. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomed. 5, 1595–1616.

Dizaj, S. M., 2013, Preparation and Study of Vitamin A Palmitate Microemulsion Drug Delivery System and Investigation of Co-surfactant Effect, Journal of Nanostructure in Chemistry, 3 (59), 2-6.

Ekowati, J., Widyowati, R.R., & Isadiartuti, D., 2017, Preparation of An Inclusion Complex System of Ethyl p-Methoxycinnamate-Hydroxypropyl-β-Cyclodextrin: Characterization and Solubility Evaluation, Research Journal of Pharmaceutical, Biological, and Chemical Sciences, 8(1), 1486-1494

Ernawati, T., Radji, M., Hanafi, M., Muni’im, A., & Yanuar, A., 2017, Cinnamic Acid Derivates as alfa-Glucosidase Inhibitor Agents, Indones. J. Chem, 17(1):151-160.

Lin, Y.-M., Wu, J.-Y., Chen, Y.-C., Su, Y.-D., Ke, W.-T., Ho, H.-O., & Sheu, M.-T., 2011. In situ formation of nanocrystals from a self-microemulsifying drug delivery system to enhance oral bioavailability of fenofibrate, Int. J. Nanomedicine, 6, 2445–2457.

Makadia, H.A., Bhatt, A.Y., Parmar, R.B., Jalpa, S.P., & Tank, H.M, 2013, Self-nano Emulsifying Drug Delivery System (SNEDDS): Future Aspects, Asia. J. Pharm. Res, 3(1), 21-27.

Patel, M.J., Patel, N.., & Patel, M.., 2010. A Self-Microemulsifying Drug Delivery System (SNEDDS). Int J Pharm Sci 4, 29–33.

Priani , S.E., Nurrayyan, & Darusman, F., 2017, Formulation Self Nano Emulsifying Drug Delivery System Glimepiride using Oleic Acid as Oil Phase, Pharmaciana, 7(2), 267-276.

Riasari, H., Revika R, & Febriani, Y., 2016, Effectiveness of Anti-Inflammatory Plaster from Kencur (Kaempfaria galanga L.) Rhizome Ethanol Extract, IJPSR, 7(4), 1746-1749.

Rowe, R.C., Sheskey, P.J., & Quinn, M.E., 2009, Handbook of Pharmaceutical Excipients, 6th Edition, Pharmaceutical Press and American Pharmacist Association, Washington D.C.

Tambunan L.Z., & Lubis, W.H., 2016, Effectiveness of Kaempferia Galanga Linn Rhizome’s Extract Towards the Healing of Minor Recurrent Aphthous Stomatitis in RSGMP USU’s Patients, UIP Health Med, 1(1), 100-103.

Umar, M.I, Asmawi, M.Z, Sadikun A., Item J., Yam, M.F, Altaf, R., & Ahmed, A., 2012, Bioactivity-Guided Isolation of Ethyl-p-methoxycinnamate, an Anti-inflammatory Constituent, from Kaempfaria galanga L. Extracts, Molecules, 17:8720-8734.

Villar, A.M, Naveros, B.C, Campmany, A.C, Trenchs, M.A, Rocabert, C.B., & Bellowa, L.H, 2012, Design and Optimization of Self-Nanoemulsifying for Enhanced Dissolution of Gemfibrozil, Int. J. of Pharmaceutics, 431(1-2), 161-175.

Wahyuningsih, I., Widyaningsih, W., & Wulandari, S., 2018, Reducing Ulcerogenic Effect of Self-Nanoemulsifying Drug Delivery System of Piroxicam, Pharmaciana, 8(2), 241-248

Yuwono, T., Binarjo, A., & Priyanto, R., 2015, Development of Cosolvent Method Preparation of Thymoquinone-Chitosan Nanoparticle using Isopropil Alcohol, Pharmaciana, 5(2), 121-130.

Downloads

Published

2022-11-14

Issue

Vol. 12 No. 3 (2022): Pharmaciana

Section

Pharmaceutics and Pharmaceutical Technology

License

Authors who publish with Pharmaciana agree to the following terms:

  1. Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.