Effect of virgin coconut oil (VCO) on the physical stability of sweet potato leaf extract (Ipomoea batatas (L.) Lam) creams and antibacterial activity test against Staphylococcus aureus ATCC 25923
DOI:
https://doi.org/10.12928/pharmaciana.v11i1.18575Keywords:
sweet potato leaves, cream, VCO, physical test, antibacterialAbstract
VCO (virgin coconut oil) has benefits for skin health such as softening the skin, maintaining skin health, and protecting the skin from radiation and free radicals. VCO as one of the raw materials for making cream preparations can affect its physical stability. This study aimed to analyze the effect of VCO on the physical stability of sweet potato leaf extract creams and antibacterial activity test against Staphylococcus aureus ATCC 25923. The creams were made with five formulas namely base, extract cream 2%, and VCO 1%, 3%, 5% added to the extract cream 2% respectively. Physical stability test included storage for six weeks at room temperature. Stability parameters were organoleptic observation, homogeneity, pH, spreadability, adhesivity, and cream type. Statistical analysis was carried out with the Anova and Kruskal Wallis tests. The organoleptic test results of the cream extract showed a distinctive odor, green color, with semisolid and homogeneous texture. Increasing the concentration of VCO will increase the spreadability of extract cream but did not affect pH and adhesion. The conclusion of this study was that extract cream 2% without the addition of VCO was the most stable cream formulation. Besides that, all the cream formulas did not show antibacterial activity against Staphylococcus aureus ATCC 25923.
References
Arbie, S., Sugihartini, N., & Wahyuningsih, I. (2020). Formulasi krim M/A dengan variasi konsentrasi ekstrak buah pepaya (Carica papaya L.) menggunakan emulgator asam stearat dan rrietanolamin. Media Farmasi, 16(1), 97–104. https://doi.org/https://doi.org/10.32382/mf.v16i1.1420
Azkiya, Z., Ariyani, H., & Setia Nugraha, T. (2017). Evaluasi sifat fisik krim ekstrak jahe merah (Zingiber officinale Rosc. var. rubrum) sebagai anti nyeri. Current Pharmaccutica Sciences, 1(1), 12–18.
Cahyani, N. P. S. E., Susiarni, J., Dewi, K. C. S., Melyandari, N. L. P., Putra, K. W. A., & Swastini, D. A. (2019). Karakteristik dan skrining fitokimia ekstrak etanol 70% batang Kepuh (Sterculia foetida L.). Jurnal Kimia, 13(1), 22–28. https://doi.org/10.24843/jchem.2019.v13.i01.p04
Cahyati, A. N., Ekowati, D., & Harjanti, R. (2015). Optimasi kombinasi asam stearat dan trietanolamin dalam formula krim ekstrak daun Legetan sebagai antioksidan secara Simplex Lattice Design. Jurnal Farmasi Indonesia, 12(1), 60–69.
Darma, W., & Marpaung, M. P. (2020). Analisis jenis dan kadar saponin ekstrak akar kuning (Fibraurea chloroleuca Miers) secara gravimetri. Dalton: Jurnal Pendidikan Kimia Dan …, 3(1), 51–59. https://ojs.uniska-bjm.ac.id/index.php/daltonjurnal/article/view/3109
Deepa, M., & Padmaja, C. K. (2014). Preliminary phytochemical analysis and thin layer chromatography of the extracts of excoecaria Agallocha L. International Journal of Pharmaceutical Sciences and Research, 5(10), 4535–4542.
Dipahayu, D., Soeratri, W., & Agil, M. (2014). Formulasi krim antioksidan ekstrak etanol daun ubi jalar ungu (Ipomoea batatas (L.) Lamk) sebagai anti aging. Pharmaceutical Sciences and Research, 1(3), 166–179. https://doi.org/10.7454/psr.v1i3.3485
Elmitra, E., & Rikomah, S. E. (2018). Formulasi sediaan krim ekstrak etanol daun puding hitam (Graptophyllum Pictum (L.) Griff). Jurnal Katalisator, 3(1), 43–52. https://doi.org/10.22216/jk.v3i1.2297
Farah, J., Yuliar, & Marpaung, M. P. (2019). Ekstrak etil asetat daun jambu biji merah (Psidium guajava L.) sebagai antioksidan secara in vitro. JFL : Jurnal Farmasi Lampung, 8(2), 78–86. https://doi.org/10.37090/jfl.v8i2.143
Hasnaeni, H., Usman, S., & Wisdawati, W. (2019). Pengaruh metode ekstraksi terhadap rendemen dan kadar fenolik ekstrak tanaman kayu Beta-beta (Lunasia amara Blanco). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 5(12), 175–182. https://doi.org/10.22487/j24428744.0.v0.i0.13599
Hastuti, S. (2017). Pengaruh pemberian VCO ( Virgin Coconut Oil ) terhadap stabilitas salep ekstrak etil asetat daun Seligi ( Phyllanthus buxifolius Muell . Arg ). Indonesian Journal On Medicine Science, 4(2), 157–163.
Indriaty, S., Hidayati, N. R., & Bachtiar, A. (2018). Bahaya kosmetika pemutih yang mengandung merkuri dan hidroquinon serta pelatihan pengecekan registrasi kosmetika di rumah sakit gunung Jati Cirebon. Jurnal Surya Masyarakat, 1(1), 8–11. https://doi.org/10.26714/jsm.1.1.2018.8-11
Lalu, M. G., Nursamsiar, M, L., & Gani, S. A. (2017). Sunscreen Activiting of Purple Sweet Potato (Ipomoea batatas L.) Using Spectrofotometry Method. Journal of Pharmaceutical and Medicial Sciences, 2(1), 27–31.
Li, Z., Xie, D., Sun, Z., Zhang, D. H., Lin, S. Y., & Guo, H. (2009). NH (X3 σ) +H/D (S2) →h (S2) +NH/ND (X3 σ) exchange reactions: State-to-state quantum scattering and applicability of statistical model. Journal of Chemical Physics, 131(12), 192–201. https://doi.org/10.1063/1.3241134
Lumentut, N., Edy, H. J., & Rumondor, E. M. (2020). Formulasi dan uji stabilitas fisik sediaan krim ekstrak etanol kulit buah pisang Goroho (Musa acuminafe L.) konsentrasi 12.5% sebagai tabir surya. Jurnal MIPA, 9(2), 42–46. https://doi.org/10.35799/jmuo.9.2.2020.28248
Margata, L., Silalahi, J., Harahap, U., Suryanto, D., & Satria, D. (2019). The antibacterial effect of enzymatic hydrolyzed virgin coconut oil on Propionibacterium acne, Bacillus subtilis, Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus. Rasayan Journal of Chemistry, 12(2), 987–993. https://doi.org/10.31788/RJC.2019.1225113
Marjoni, M. R. (2016). Dasar-dasar fitokimia untuk diploma III farmasi. Trans Info Media.
Meilina, N. E., & Hasanah, N. A. (2018). Review artikel: Aktivitas antibakteri ekstrak kulit Manggis (Garcinia mangostana L.) terhadap bakteri penyebab jerawat. Jurnal Farmaka, 16(2), 322–328.
Mu’awanah, I., Setiaji, B., & Syoufian, A. (2014). Pengaruh Konsentrasi Virgin Coconut Oil (VCO) Terhadap Stabilitas Emulsi Kosmetik dan Nilai Sun Protection Factor (SPF). BIMIPA, 24(1), 1–11. https://doi.org/10.30595/pji.v13i02.1256 10.30595/pji.
Nomer, N. M. G. R., Duniaji, A. S., & Nocianitri, K. A. (2019). Kandungan senyawa flavonoid dan antosianin esktrak kayu secang (Caesalpinia sappan L.) serta aktivitas antibakteri terhadap Vibrio cholerae. Jurnal Ilmu Dan Teknologi Pangan (ITEPA), 8(2), 216–225. https://doi.org/10.24843/itepa.2019.v08.i02.p12
Nonci, F. Y., Tahar, N., & Aini, Q. (2016). Formulasi dan uji stabilitas fisik krim susu Kuda Sumbawa dengan Emulgator Nonionik dan Anionik. Jurnal Farmasi UIN Alauddin Makassar, 4(4), 169–178.
Osuntokun, O. T., Yusuf-Babatunde, M. A., & Fasila, Oladele, O. (2020). Components and Bioactivity of Ipomoea batatas (L.) (Sweet Potato) Ethanolic Leaf Extract. Asian Journal of Advanced Research and Reports, 10(1), 10–26. https://doi.org/10.9734/ajarr/2020/v10i130232
Rahim, F., Aria, M., & Aji, N. P. (2011). Formulasi krim ekstrak etanol daun Ubi Jalar (Ipomoeae batatas L.) untuk pengobatan luka bakar. Scientia : Jurnal Farmasi Dan Kesehatan, 1(1), 21–26. https://doi.org/10.36434/scientia.v1i1.12
Rangotwat, A., YamLean, P. V. ., & Lolo, Wi. A. (2016). Formulasi dan uji antibakteri sediaan losio ekstrak metanol daun ubi jalar ungu (Ipomoea batatas POIR) terhadap bakteri Staphylococcus aureus. Pharmacon, 5(4), 90–98. https://doi.org/10.35799/pha.5.2016.13978
Saryanti, D., Setiawan, I., & Safitri, R. A. (2019). Optimasi formula sediaan krim M/A dari ekstrak kulit pisang kepok (Musa acuminata L.). Jurnal Riset Kefarmasian Indonesia, 1(3), 225–237. https://doi.org/https://doi.org/10.33759/jrki.v1i3
Setiawan, A., Ayatri, R. D., Niswantari, N., & Rusli, N. (2019). Penggunaan emulgator VCO (Virgin Coconut Oil) dalam sediaan krim transdermal asetosal. Warta Farmasi, 8(2), 81–90. https://doi.org/10.46356/wfarmasi.v8i2.120
Shovyana and Zulkarnain. (2013). Stabilitas fisik dan aktivitas krim W/O ekstrak etanolik buah mahkota dewa (Phaleria macrocarph(scheff.) Boerl) sebagai tabir surya. Trad. Med. J, 18(2), 110.
Susanto, A., Hardani, & Rahmawati, S. (2019). Uji skrining fitokimia ekstrak etanol daun ubi jalar ungu (Ipomoea Batatas L). ARTERI : Jurnal Ilmu Kesehatan, 1(1), 1–7. https://doi.org/10.37148/arteri.v1i1.1
Ugochukwu, S. C., I., A. U., & Ifeanyi, O. (2013). Preliminary phytochemical screening of different solvent extracts of stem bark and roots of Dennetia tripetala. Asian Journal of Plant Science and Research, 3(3), 10–13.
Ulfa, A. M., Marcellia, S., & Rositasari, E. (2020). Efektivitas formulasi krim ekstrak kulit jeruk nipis (Citrus aurantifolia-pericappium) sebagai pengobatan luka sayat stadium II pada tikus putih (Rattus novergicus) galur wistar. Jurnal Farmasi Malahayati (JFM), 3(1), 42–52. http://www.ejurnalmalahayati.ac.id/index.php/farmasi/article/view/2434
Widiayanti, A. R. (2015). Pemanfaatan kelapa menjadi VCO (Virgin Coconut Oil) sebagai antibiotik kesehatan dalam upaya mendukung visi Indonesia sehat 2015. Prosiding Seminar Nasional Pendidikan Biologi 2015, 577–584.
Zulkarnain, O., & Ferdiana, S. (2020). Perbedaan metode pembuatan VCO antibakteria terhadap sifat Fisikokimia, dan uji organoleptik, Antibakteri VCO terhadap Bakteri Staphylococcus Aureus. Jurnal Gizi, 9(1), 124–130. https://doi.org/10.26714/jg.9.1.2020.124-130
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