EFEK HEPATOPROTEKTIF SERBUK AKAR PASAK BUMI (Eurycoma longifolia Jack.) DILIHAT DARI AKTIVITAS SGPTSGOT TIKUS JANTAN YANG DIINDUKSI CCl4

Authors

  • Wirawan Adikusuma Universitas Ahmad Dahlan
  • Moch. Saiful Bachri Universitas Ahmad Dahlan

DOI:

https://doi.org/10.12928/pharmaciana.v4i2.1574

Keywords:

Eurycoma longifolia Jack., hepatoprotective, SGPT-SGOT, CCl4

Abstract

This study was designed to evaluate the hepatoprotective effect of the powder Eurycoma
longifolia Jack. From the activity level of SGPT-SGOT on CCl4-induced in male rats. Twenty
five male rats (150-250 g) divide in to 5 groups. Group I treated with aquadest was kept as
normal, group II treated with a single dose of CCl4 (1 ml/ kg BW i.p), group III and IV were
treated with Eurycoma longifolia Jack. (100 mg/kg BW and 200 mg/kg BW p.o) respectively
and CCl4 (1 ml/kg BW i.p), group V treated with a single dose of curcumin (100 mg/kg BW
p.o) and CCl4 (1 ml/kg BW i.p). Blood was collected from vena porta for determination of
SGPT-SGOT. The study showed the activity level of SGPT from the rats was treated by
Eurycoma longifolia Jack. 100 mg/kg BW and 200 mg/kg BW, Curcumin, and control groups
are 150.0±5.099 U/L; 113.6±5.508 U/L; 60.5±2.887 U/L; and 129.0±6.055 U/L respectively.
Mean while the activity level of SGOT from the rats was treated by Eurycoma longifolia Jack.
100 mg/ kg BW and 200 mg/ kg BW, Curcumin, and control groups are 369.4±11.165;
263.0±1.803; 194.5±7.448; and 451.5±16.759 U/L respectively. The Eurycoma longifolia
Jack. powder and Curcumin significantly (p < 0.05) declines two enzymes (SGPT and SGOT)
than control group. The results concluded that Eurycoma longifolia Jack. powder has
hepatoprotective effect.

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Published

2014-11-01

Issue

Vol. 4 No. 2 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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