PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA

Authors

  • Hardi Astuti Witasari
  • Rizaldy Taslim Pinzon
  • Erna Kristin

DOI:

https://doi.org/10.12928/pharmaciana.v4i2.1572

Keywords:

Ischemic stroke, aspirin resistance, diabetes mellitus

Abstract

The secondary prevention of ischemic stroke can be implemented by giving aspirin.
However, some cases of aspirin resistance have been found. The purpose of this study was to
examine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic stroke
patients at Bethesda Hospital Yogyakarta. This study was using a nested case-control study
design. The Cases group was subjects who resistance to aspirin therapy. The control group was
subjects who response to aspirin therapy. The factors that affect the incidence of aspirin
resistance were analyzed by bivariate analysis chi square test. The proportion of diabetes
mellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was
1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at Bethesda
Hospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirin
resistance than the patients without diabetes mellitus.

Downloads

Published

2014-11-01

Issue

Vol. 4 No. 2 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

License

Authors who publish with Pharmaciana agree to the following terms:

  1. Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.