STUDI KELARUTAN PROPAGERMANIUM DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI

Authors

  • Widyasari Putranti
  • Suwaldi Martodihardjo
  • Endang Lukitaningsih

DOI:

https://doi.org/10.12928/pharmaciana.v4i2.1569

Keywords:

solubility, HPLC, propagermanium, pH, validation

Abstract

Propagermanium, a synthetic organic compound of germanium is known as β- or biscarboxyethylgermanium
sesquioxide or Ge-132. It is found in some plants such as shelf fungus,
ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effects
of the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Until
now, the analytical methods for the analysis of Ge-132 so far have the shortcoming and the
propagermanium as germanium metal in the sample, so that improvement for propagermanium
analysis was necessary to be conducted, primarily to be used for solubility assay. This study
aims to determine the effects of pH on the propagermanium solubility using HPLC method for
analysis. The results showed that validation parameters for analysis by using HPLC method e.i
accuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasing
the pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. The
solubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.

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Published

2014-11-01

Issue

Vol. 4 No. 2 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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