SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT

Authors

  • Artie Noor Pratiwi
  • Nurkhasanah Mahfudh

DOI:

https://doi.org/10.12928/pharmaciana.v4i2.1563

Keywords:

Organic Syntesis Organik, 1, 10-phenantroline, antimalarial, 2-nitrobenzyl chloride

Abstract

The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized by
nucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with
1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.
Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantroline
monohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determined
based on the melting range data and TLC. Identification of the structure of the compounds
synthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is a
colorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with an
optimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount of
yield product, there is an optimal yield in the mole ratio of 1:1.

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Published

2014-11-17

Issue

Vol. 4 No. 2 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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