Exercise and consumption of herbal remedies decrease the risk of strokes in hypertension and diabetes mellitus patients undergoing a standard therapy
DOI:
https://doi.org/10.12928/pharmaciana.v9i2.13143Keywords:
stroke risk factors, physical exercises, herbal medicine, smoke, diabetes mellitusAbstract
Stroke is a serious problem faced worldwide. It can result in death, physical disability, and mental disability. Hypertension and Diabetes Mellitus (DM) patients are high-risk populations. The study attempted to determine the factors associated with the incidence of stroke in DM or hypertension outpatients. This analytic observational study used a case-control design and nonrandom sampling technique with consecutive sampling approach. With a 1:2 ratio, the subjects consisted of 49 stroke patients in the case group and 98 non-stroke patients (hypertensive) for the control group. Subjects were patients undergoing treatments at PKU Muhammadiyah Hospital in Bantul. Patient's lifestyle data were collected through face-to-face interviews with patients, while demographic information, diagnosis, and patient history were obtained from medical records using data retrieval forms (case record forms). The variable age was matched with sex to improve the efficiency and accuracy of the study. Data analysis included univariate (descriptive) analysis and bivariate analysis using the Chi-Square test. Factors associated with stroke incidence were smoking habit (OR = 2.940, CI: 1.314 <OR <6.576; P = 0.007), exercise routine (OR = 0.026, CI: 0.008 <OR <0.079, P = 0.000), high-fat food dietary pattern (OR = 3.629, CI: 1.119 <OR <11.766; P = 0.024), and the habit of consuming herbal remedies (OR = 0.299, CI: 0.107 <OR <0.833; P = 0.016). Â For hypertension or DM patients who took standard therapy at PKU Muhammadiyah Hospital in Bantul, smoking and fatty food consumption increased the risk of stroke, whereas physical exercise and herbs consumption habits reduced it.
References
AHA, 2010, Heart disease and stroke statistics – 2010 Update. Dallas, Texas: American Heart Association.
Amrun, H.M, Umiyah, and Evi Umayah U., 2007, Uji Aktifitas Antioksidan Ektrak Air dan Ektrak Metanol Beberapa Varian Buah Kenitu (Chrysophyllum cainito L) dari daerah Jember, Berk. Penel. Hayati.
Baldwin, K., Orr, S, Briand, M., Piazza, C., Veydt, A., and McCoy S., 2010, Acute ischemic stroke update from pharmacotherapy. J Medscape.
Bhatt, Malik, and Chaturvedi., 2008, Dose-Response Relationship Between Cigarette Smoking And Risk Of Ischemic Stroke In Young Women, Stroke, 39(9): 2439–2443.
Burhanuddin, M., Wahiduddin., and Jumriani., 2012, Faktor Risiko Kejadian Stroke pada Dewasa Awal (18-40 tahun) di Kota Makassar tahun 2010-2012. Research Article. Makassar: Universitas Hassanudin.
Cheng, Y.-C. Sheen, J.M., Hu, W.L., Hung, Y.C., 2017, Polyphenols And Oxidative Stress In Atherosclerosis-Related Ischemic Heart Disease And Stroke, Oxidative Medicine and Cellular Longevity, 2017: 1–16.
Dahrizal, 2009, Pola makan dan hiperurisemia sebagai faktor risiko kejadian stroke pada pasien yang dirawat di rumah sakit Mayjen H.A. Thalib Kabupaten Kerinci. Research Report. Bagian Ilmu Kesehatan Masyarakat FK UGM, Yogyakarta.
Dinata, C.A., Safitra, Y., and Sastri, S., 2013, Gambaran faktor risiko dan tipe stroke pada pasien rawat inap di bagian penyakit dalam rsud kabupaten solok selatan periode 1 januari 2010 - 31 juni 2012. Jurnal Kesehatan Andalas, 2(2): 57-61.
Dourman, 2013, Waspadai Stroke Usia Muda. Jakarta: Cerdas Sehat.
Dröge, W., 2002, Free Radicals in the Physiological Control of Cell Function’, Physiological Reviews, 82(1): 47–95.
Erphinz, 2008, Peningkatan Kolesterol LDL Sebagai Faktor Risiko Stroke. http://strokebethesda.com/component/option.com.
Furie, K. L., Kasner, S. E., Adams, R. J., Albers, G. W., Bush, R. L., Fagan, S. C., et al., 2011. Guidelines For The Prevention Of Stroke In Patients With Stroke Or Transient Ischemic Attack: A Guideline For Healthcare Professionals From The American Heart Association/American Stroke Association. Stroke, 42(1), 227–276.
Halliwell, B., and Gutteridge, J.M.C., 2007, Free radicals in biology and medicine. 4th eds. New York: Oxford.
Hernani and Rahardjo., 2005, Tanaman Berkhasiat Antioksidan. Jakarta: Penebar Swadaya.
Jain, S. Buttar HS, Chintameneni M, Kaur G., 2018, Prevention of Cardiovascular Diseases with Anti-Inflammatory and Anti- Oxidant Nutraceuticals and Herbal Products: An Overview of Pre-Clinical and Clinical Studies, Recent Patents on Inflammation and Allergy Drug Discovery, 12(2): 145–157.
Jannah, N. 2001, Faktor-faktor risiko terjadinya stroke perdarahan di ruang rawat inap RSUD Dr. Soetomo. Skripsi. Surabaya, Universitas Airlangga.
Janssen, A. W. M., de Leeuw, F. E. and Janssen, M. C. H., 2011, Risk Factors For Ischemic Stroke And Transient Ischemic Attack In Patients Under Age 50, Journal of thrombosis and thrombolysis. Springer, 31(1): 85–91.
Junaidi, I. 2006, Stroke A-Z. PT Bhuana Ilmu Populer, Jakarta.
Junaidi, I. 2011, Stroke Waspadai Ancamannya. Yogyakarta: ANDI.
Kim, J. Y. Kang K, Kang J, Koo J, Kim DH, Kim BJ, et al., 2019, Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society. Journal of stroke. Korean Stroke Society, 21(1): 42–59.
Kristiyawati, S.P., Irawaty, D., and Hariyati, Rr.T.S., 2009, Faktor Risiko yang Berhubungan de-ngan Kejadian Stroke di RS Panti Wilasa Citarum Sema-rang, Jurnal Keperawatan dan Kebidanan (JIKK). Semarang: STIKES Telogorejo, 1(1): 1-7.
Lee, J., Son, H. and Ryu, O. H., 2017, Management Status of Cardiovascular Disease Risk Factors for Dyslipidemia among Korean Adults., Yonsei medical journal. Yonsei University College of Medicine, 58(2): 326–338.
Lemeshow, S. 1997, Besar Sampel dalam Penelitian Kesehatan. Gadjah Mada University. Yogyakarta.
Lennon, O. Blake, C., Lawrence, M., 2018, Interventions For Behaviour Change And Self-Management In Stroke Secondary Prevention: Protocol For An Overview Of Reviews., Systematic Reviews. BioMed Central, 7(1): 231.
Llyoid-Jones, D., Adams, RJ., Brown, T.M., Carnethon, M., Dai, S., De Simone, G.,Ferguson, T.B., Ford, E., Furie, K., Gillespie; C., Go, A., Greenlund, K., Haase, N., Hailpern, S., 2010. Executive Summary: Heart Disease and Stroke Statistics—2010 Update, Circulation, 121(7), February 23, 2010.
Luepker, R.V., Evans, A., Mckeigue, P., and Reddy K.S., 2004, Cardiovascular Survey Methods. Geneva: WHO.
Lipska, K. Sylaja, P.N., Sarma, P.S., Thankappan, K., Kutty, V.R., Vasan, R.S., Radhakrishnan, K., 2007, Risk Factors For Acute Ischaemic Stroke In Young Adults In South India., Journal of neurology, neurosurgery, and psychiatry. BMJ Publishing Group, 78(9): 959–63.
Mendis, S., Puska, P., and Norrving, B., 2011, Global Atlas On Cardiovascular Disease.World Health Organization, World Heart Federation, World Stroke Organization.
Nabyl, R. A., 2012, Panduan hidup sehat: Mencegah dan Mengobati Diabetes Melitus. Aulia publishing. Yogyakarta.
Naqvi, S. Naveed, S., Ali, Z., Ahmad, S.M., Asadullah, R., 2017, Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus, Cureus, 9(6): e1347.
O’Donnell, M. J., Chin, S. L., Rangarajan, S., Xavier, D., Liu, L., Zhang, H., Yusuf, S. 2016, Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. The Lancet, 388(10046): 761–775.
Puspita, M.R., and Putro, G. 2008, Hubungan Gaya Hidup terha-dap Kejadian Stroke di Rumah Sakit Umum daerah Gambiran Kediri, Buletin Penelitian Sistem Kesehatan.
Rambe, A., 2006, Stroke: Sekilas Tentang Definisi, Penyebab, Efek, dan Faktor Risiko. Medan: Majalah Kedokteran Nusantara, 10 (2): 195-198.
Rastogi, S., Pandey, M. M. and Rawat, A. K. S., 2016, Traditional Herbs: A Remedy Fo Cardiovascular Disorders, Phytomedicine, 23(11): 1082–1089.
Rastogi, S., Pandey, M. M. and Rawat, A. K. S., 2017, Spices: Therapeutic Potential in Cardiovascular Health, Current Pharmaceutical Design, 23(7): 989–998.
Riset Kesehatan Dasar (Riskesdas). 2013, Badan Penelitian dan Pengembangan Kesehatan Kementerian RI tahun 2013. Accessed: August 20, 2016, from http://www.depkes.go.id/resources/download/general/Hasil%20Riskesdas%20 2013.pdf.
Rohmatussolihat, 2009. Antioksidan, Penyelamat Sel-Sel Tubuh Manusia, BioTrends, 4(1):5-9.
Sastroasmoro, 2002, Dasar-Dasar Metodologi Penelitian Penelitian Klinis. Jakarta: CV. Sagung Seto.
Silva, D.A., Venketasubramanian, N., Roxas, A.A., Kee, L.P., and Lampl, Y., 2014, Understanding Stroke. A Guide For Stroke Survivor and Their Families. Moleac: www.neuroaid.com : 1-384.
Smith SC Jr, Allen J, Blair SN, Bonow RO, Brass LM, Fonarow GC, et al., 2006, AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update, Circulation. Lippincott Williams and Wilkins, 113(19): 2363–2372.
Sofyan, A.M., Sihombing, I.Y., and Hamra, Y., 2012, Hubungan Umur, Jenis Kelamin, dan Hipertensi dengan Kejadian Stroke. Program Pendidikan Dokter FK UHO.
Stroke Association, 2010, Converging Risk Factors. January 4, 2017. www.strokeassosiation.org.
Sutrisno, A. 2007, Stroke? You Must Know Before You Get It. Jakarta: Gramedia Pustaka Utama.
Tomi., Akrom., and Jatiningrum, A., 2016. Gambaran Medication Error Pada Fase Prescribing dan Administrasi Pada Pengobatan Stroke di IGD Rumah Sakit X di Yogyakarta. Thesis, Magister Farmasi Klinis Universitas Ahmad Dahlan.
Viveca M.Bhat., JohnW. Cole., John D. Sorkin., Marcella A. Wozniak., Ann M.Malacher., Wayne H, Giles., Barney J. Stern., Steven J., Kittner., 2008, Dose-Response Relationship Between Cigarette Smoking and Risk of Ischemic Stroke in Young Women. Journal of The American Stroke Association, 39(9):2439-2443.
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