In vitro immunomodulatory activity test of Bengle rhizoma extract (Zingiber cassumunar Roxb.): phagocytic activity of macrophages and lymphocyte proliferation in mice

Authors

  • Ghina Adhila Ahmad Dahlan University
  • Nurkhasanah Nurkhasanah Farmasi, Universitas Ahmad Dahlan
  • Nanik Sulistyani Farmasi, Universitas Ahmad Dahlan

DOI:

https://doi.org/10.12928/pharmaciana.v9i2.12881

Keywords:

Zingiber cassumunar, immunomodulator, phagocytic activity of macrophages, lymphocyte proliferation

Abstract

Immunomodulators are pharmacological agents that affect the immune system at different levels. Aside from modulating, some immunomodulators stimulate, while some others inhibit immune responses. Zingiber cassumunar Roxb. or Bengle rhizoma has been reported to exhibit immunomodulatory activities. This research was intended to determine the pharmacological effects of its extract on the phagocytic activity  of  macrophages and lymphocyte proliferation in vitro. It used the macrophages and lymphocytes of male BALB/c mice, which were divided into normal control and treatment group (receiving 25, 50, and 100 ppm of extract). The immunomodulatory activity test results showed that 100 ppm of Bengle rhizoma extract reduced phagocytosis in macrophages much significantly than the control group and that the treatment groups suppressed the proliferation of lymphocytes more  substantially than the control group. The extract decreased the phagocytic activity of macrophages and the proliferation capacity of lymphocytes when administered at a concentration of 100 ppm.

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Published

2019-11-30

Issue

Vol. 9 No. 2 (2019): Pharmaciana

Section

Pharmacology

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