Studi Pharmacovigilance Obat Herbal Di Puskesmas Kasihan II Bantul

Authors

  • Nur Mahdi Fakultas Farmasi Universitas Muhammadiyah Banjarmasin
  • Dyah Aryani Perwitasari Fakultas Farmasi Universitas Ahmad Dahlan
  • Nyoman Kertia Fakultas Kedokteran Universitas Gajah Mada

DOI:

https://doi.org/10.12928/mf.v13i1.5744

Abstract

Kejadian Reaksi Obat yang Tidak Dikehendaki (ROTD) dari obat-obat herbal merupakan hal yang masih jarang diteliti di Indonesia. Gaya hidup kembali ke alam menjadi cukup popular saat ini, sehingga masyarakat kembali memanfaatkan berbagai bahan alam, termasuk pengobatan dengan tumbuhan obat atau herbal. Dengan meningkatnya penggunaan obat herbal di Indonesia, maka diperlukan pemantauan keamanan pada obat-obat herbal.  Tujuan penelitian ini adalah mengetahui gambaran kausalitas kejadian ROTD serta mengetahui kualitas hidup pasien yang mendapatkan resep obat herbal. Penelitian ini menggunakan rancangan observasional deskriptif, pengambilan data secara consecutive sampling secara prospektif. Pengambilan data selama dua bulan saat penelitian berlangsung, setelah itu dianalisis kejadian ROTD dan tanpa ROTD serta dinilai kualitas hidup pasien. Instrumen yang digunakan untuk menganalisis adalah algoritma Naranjo dan kuesioner SF-36. Hasil wawancara kepada 25 subyek penelitian pada pengamatan prospektif dan retrospektif, subyek yang melaporkan adanya kejadian ROTD sebanyak 3 subyek (12%). Sebanyak 2 subyek dengan kategori possible (mungkin) dan 1 subyek dengan kategori probable (cukup mungkin). ROTD yang muncul adalah gatal-gatal, nyeri pinggang, mual, ngantuk dan dada berdebar. Kesimpulan dari penelitian ini adalah terdapat kejadian ROTD pada pasien yang diberikan terapi herbal, gambaran kausalitas kejadian ROTD adalah kategori possible dan probable.

 

Kata kunci: pharmacovigilance, reaksi obat yang tidak dikehendaki, obat herbal.

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Issue

Vol. 13 No. 1: Maret 2016

Section

Pharmaceutical & Technology

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