Aktivitas Inhibisi A-Amilase Ekstrak Karagenan dan Senyawa Polifenol dari Eucheuma denticulatum

Authors

  • Agung Giri Samudra Akademi Farmasi Al-Fatah
  • Agung Endro Nugroho Bagian Farmakologi Farmasi Universitas Gajah Mada Yogyakarta
  • Amir Husni Mikrobiologi Perikanan Universitas Gajah Mada Yogyakarta

DOI:

https://doi.org/10.12928/mf.v12i1.3023

Abstract

Penelitian ini untuk mengetahui kemampuan karagenan dan polifenol dari
Eucheuma denticulatum terhadap karbohidrat enzim α-amilase secara in vitro. Ekstrasi karagenan menggunakan larutan kalium hidroksida 0,5%. Polifenol diekstraksi dengan 50% (v/v) metanol. Identifikasi karagenan ditentukan dengan Fourier Transform Infrared (FTIR). Kandungan total fenol ekstrak ditentukan menurut metode Folin-Ciocalteu. Kemudian hasil ekstraksi diuji daya hambat aktivitas α-amilase. Ekstrak karagenan dan polifenol mempunyai kemampuan menghambat aktivitas IC50  α-amilase yaitu 12,16 dan  11,64 mg/mL. Ekstrak Polifenol   memiliki daya hambat α-amilase lebih tinggi dari pada ekstrak karagenan.

Kata Kunci: Eucheuma denticulatum, karagenan, polifenol, α-amilase.

Downloads

Issue

Vol. 12 No. 1: Maret 2015

Section

Pharmaceutical & Technology

License

Authors who publish with Media Farmasi agree to the following terms:

  1. Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Lisensi Creative Commons

This work is licensed under a Creative Commons Attribution 4.0 International License