Formulation of Body Lotion Ethanol Extract of Kepundung Bark (Baccaurea Macrocarpa (Miq.) Mull Arg.) and Antioxidant Activity Test

Authors

  • Noni Rahayu Putri Universitas Perintis Indonesia
  • Tisa Mandala Sari Universitas Perintis Indonesia
  • Sri Rahma Z

Keywords:

Antioxidant, Baccaurea Macrocarpa, Body lotion ,DPPH

Abstract

The bark of kepundung (Baccaurea macrocarpa (Miq.) Mull Arg.) contains secondary metabolite compounds from polyphenols such as flavonoids, phenolic, terpenoids, and alkaloids, which have the potential for natural antioxidants. This research aims to evaluate of ethanol extract from kepundung bark and formulate the body lotion to test its antioxidant activity using the DPPH method. Body lotion formulas were made with variations in the concentration 0.4, 1.0, and 1.6% of ethanol extract of kepundung bark as active ingredients. The evaluation of body lotion included organoleptic, pH, homogeneity, type of body lotion, stability, viscosity, irritation, and antioxidant activity tests. The results of the physical evaluation of the body lotion meet the requirements. Namely, all formulas are homogeneous, according to skin pH, the viscosity of the preparation ranges from 2500 cP, stable, and does not irritate. The value IC50 antioxidant activity of ethanol extract of kepundung bark was 4.04 ppm. The value IC50 antioxidant activity body lotion at F1, F2, and F3 respect 41.91, 36.98, and 33.13 ppm. The result showed the best formula is F3 with a value IC50 33.13 ppm. Based on the study, the ethanol extract of depending bark and the body lotion has very strong antioxidant activity.

Author Biography

Noni Rahayu Putri, Universitas Perintis Indonesia

Teknologi Farmasi

References

Amatullah, L., Cahyaningrum, T., & Fidyaningsih, A. (2017). Efektifitas antioksidan pada formulasi skin lotion ekstrak Mesocarp Buah Lontar (Borassus Flabellifer) terhadap Tikus Putih Jantan Galur Wistar secara In-Situ. In Journal of Pharmaceutical Science and Clinical Research, 2(1), 25. DOI:10.20961/jpscr.v2i01.5236.

Badarinath, A. V, Rao, K. M., Madhu, C., Chetty, C. M. S., Ramkanth, S., Rajan, T. V. S., & Gnanaprakash, K. (2010). A review on in-vitro antioxidant methods: comparisions, correlations and considerations. In International Journal of PharmTech Research, researchgate.net. https://www.researchgate.net/profile/Bhavesh-Tiwari/post/Can_anyone_suggest_the_best_technique_to_estimate_the_level_of_antioxidant_compounds_in_a_plant_extract/attachment/59d62e5fc49f478072e9efd3/AS%3A273574751866880%401442236711585/download/ANTIOXIDANT+3.pdf

Chang, C. T., Chang, W. L., Hsu, J. C., Shih, Y., & Chou, S. T. (2013). Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil. In Botanical Studies. Springer. https://doi.org/10.1186/1999-3110-54-10

Erwin, E., Pusparohmana, W. R., Sari, I. P., Hairani R., and Usman, U. (2019). GC-MS profiling and DPPH radical scavenging activity of the bark of Tampoi (Baccaurea macrocarpa). In F1000Research, pmc.ncbi.nlm.nih.gov. https://pmc.ncbi.nlm.nih.gov/articles/PMC6915813/

Gozali, D., Rusmiati, D., & Utama, P. (2009). Formulasi dan Uji Stabilitas Mikroemulsi Ketokonazol Sebagai Antijamur Candida albicans dan Tricophyton mentagrophytes. In Fakultas Farmasi. Universitas Padjadjaran-Jatinangor. https://www.scribd.com/doc/75102330/Formulasi-Dan-Uji-Stabilitas-Mikroemulsi-Ketokonazol-Sebagai-Antijamur-Candida-Albicans-Dan-Tricophyton-Mentagrophytes

Haegens, R. (2000). Taxonomy, phylogeny, and biogeography of Baccaurea, Distichirhops, and Nothobaccaurea (Euphorbiaceae). Blumea. Supplement. https://repository.naturalis.nl/pub/526368

Kesehatan, R. D. (2020). Parameter Standar Umum Ekstrak Tumbuhan Obat. In D. P. O. Tradiosional (Ed.), Kesehatan (Cetakan Pertama). Scribd. https://www.scribd.com/document/637297916/Parameter-Standar-Umum-Ekstrak-Tumbuhan-1

Kholifah, E., Fitriani, V., & Shobah, A. N. (2024). Formulation and antioxidant activity analysis of Jotang Herb (Acmella paniculata) extract mask cream. Journal of Fundamental and Applied Pharmaceutical Science, 4(2), 70–80. https://doi.org/10.18196/jfaps.v4i2.19341

Kosasih, A. (2013). Ilmu Penyakit Kulit dan Kelamin Edisi 6. Jakarta: Fakultas Kedokteran UI.

Lailiyah, M., Saputra, S. A., & Sari, F. (2020). Antioxidant activity and sun protection factor evaluation for cream formulation of purified roasted corn silk extracts (Zea Mays L. Saccharata). Pharmaciana, 10(3), 371. https://doi.org/10.12928/pharmaciana.v10i3.17780

Molyneux, P. (2004). The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. In Songklanakarin J. sci. technol. academia.edu. https://www.academia.edu/download/39013361/Molineux_07-DPPH.pdf

Muslihah, H. (2007). Antioksidan Alami dan Radikal Bebas Potensi dan Aplikasi dalam Kesehatan. Yogyakarta: Kanisius.

Panjaitan, E. N., Saragih, A., & Purba, D. (2012). Formulasi gel dari ekstrak rimpang jahe merah (Zingiber officinale Roscoe) gel formulation of red ginger (Zingiber officinale Roscoe) extract. In Journal of Pharmaceutics and Pharmacology. 1(1), 9-20. https://www.semanticscholar.org/paper/Formulasi-Gel-Dari-Ekstrak-Rimpang-Jahe-Merah-Gel-(-Panjaitan-Saragih/ab34090e699073e05e166a3c557a65c62bcd0634

Prajakta, S., & Shahu, K. (2020). Formulation and evaluation of vanishing herbal cream of crude drugs. Asian Journal of Pharmaceutical Research and Development. DOI: https://doi.org/10.22270/ajprd.v8i3.725

Rabima, R. (2017). Uji stabilitas formulasi sediaan krim antioksidan ekstrak etanol 70% dari biji melinjo (Gnetum gnemon L.). Indonesia Natural Research Pharmaceutical Journal Universitas, 2(1), 107-121. https://journal.uta45jakarta.ac.id/index.php/INRPJ/article/view/834

Rohmatussolihat, R. (2015). Antioksidan, penyelamat sel-sel tubuh manusia. In Biotrends.

Safitri, C., & Jubaidah, L. (2019). Formulasi dan uji mutu fisik sediaan lotion ekstrak kulit buah jagung (Zea mays L.). In Jurnal Insan Farmasi Indonesia. 2(2), 175-184. DOI: https://doi.org/10.36387/jifi.v2i2.394

Taurhesia, S., Rosdiana, D.N., & Pratami, D.K. (2024). The Formulation and test of antioxidant activity from Serum gel of the extract Chrysanthemum flower (Chrysanthemum Indicum L.). Journal of Natural Product for Degenerative Diseases, 1(2), 57–66. DOI: https://doi.org/10.58511/jnpdd.v1i2.6376

Tirtana, E., Nora, W., & Afghani, J. (2013). Analisa proksimat, uji fitokimia dan aktivitas antioksidan pada buah tampoi (Baccaureamacrocarpa). In Jurnal Kimia Khatulistiwa, 2(1), 42-45. https://jurnal.untan.ac.id/index.php/jkkmipa/article/view/1761/1703

Zulkarnain, A. K., Marchaban, M., Wahyuono, S., & Susidarti, RA. (2016). Pengaruh konsentrasi mahkota dewa terhadap stabilitas lotion–krim serta uji tabir surya secara spektrofotometri. Majalah Farmaseutik. https://journal.ugm.ac.id/majalahfarmaseutik/article/view/24124

Published

2025-04-11

Issue

Section

Pharmaceutical & Technology