An overview of Covid-19 patients with and without comorbid Diabetes Mellitus at Surabaya Hajj general hospital

Authors

  • Uswatun Hasanah
  • Endang Darmawan Universitas Ahmad Dahlan Yogyakarta
  • Sugiyarto Sugiyarto Universitas Ahmad Dahlan

DOI:

https://doi.org/10.12928/mf.v19i2.23246

Keywords:

Covid-19, Diabetes mellitus, Random blood glucose, Death, Severity, Comorbid

Abstract

Diabetes mellitus (DM) is one of the most common comorbidities found in patients infected with Covid-19 with severity and death. To obtain an overview of Covid-19 patients with and without comorbid DM. A retrospective cohort study, taking subjective data on Covid-19 patients with and without DM at Surabaya Hajj general hospital for the period of March 2020 to June 2021. Data analysis using the Chi-square test was to determine differences in both test variables. The death of Covid-19 patients with comorbid DM was found with the condition in which the average random blood glucose (RBG) increased by >150 mg/dl (286 mg/dl), as well as in recovered patients (197 mg/dl); meanwhile, patients without comorbid DM died with also an increase in the RBG value (166 mg/dl). Male patients were found to be more prone to get infected with Covid-19 than female patients. It can be concluded that there was no significant difference in the severity of cases in Covid-19 patients with comorbid DM and without comorbid DM. Deaths due to Covid-19 in patients with comorbid DM or without comorbid DM occurs due to the increasing blood glucose value by >150 mg/dl.

Author Biographies

Uswatun Hasanah

Mahasiswa Pascasarjana Farmasi

Endang Darmawan, Universitas Ahmad Dahlan Yogyakarta

Fakultas Farmasi

Sugiyarto Sugiyarto, Universitas Ahmad Dahlan

Fakultas Sains dan Ilmu Terapan

References

Belice, T., & Demir, I. (2020). The gender differences as a risk factor in diabetic patients with covid-19. Iranian Journal of Microbiology, 12(6), 625–628. https://doi.org/10.18502/ijm.v12i6.5038

Cai, Y., Shi, S., Yang, F., Yi, B., Chen, X., Li, J., & Wen, Z. (2020). Fasting blood glucose level is a predictor of mortality in patients with COVID-19 independent of diabetes history. Diabetes Research and Clinical Practice, 169. https://doi.org/10.1016/j.diabres.2020.108437

Carrasco-Sánchez, F. J., López-Carmona, M. D., Martínez-Marcos, F. J., Pérez-Belmonte, L. M., Hidalgo-Jiménez, A., Buonaiuto, V., Suárez Fernández, C., Freire Castro, S. J., Luordo, D., Pesqueira Fontan, P. M., Blázquez Encinar, J. C., Magallanes Gamboa, J. O., de la Peña Fernández, A., Torres Peña, J. D., Fernández Solà , J., Napal Lecumberri, J. J., Amorós Martínez, F., Guisado Espartero, M. E., Jorge Ripper, C., … Gómez Huelgas, R. (2021). Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry. Annals of Medicine, 53(1), 103–116. https://doi.org/10.1080/07853890.2020.1836566

Goodman, K. E., Magder, L. S., Baghdadi, J. D., Pineles, L., Levine, A. R., Perencevich, E. N., & Harris, A. D. (2021). Impact of Sex and Metabolic Comorbidities on Coronavirus Disease 2019 (COVID-19) Mortality Risk Across Age Groups: 66 646 Inpatients Across 613 U.S. Hospitals. Clinical Infectious Diseases, 73(11), e4113–e4123. https://doi.org/10.1093/cid/ciaa1787

Jin, J. M., Bai, P., He, W., Wu, F., Liu, X. F., Han, D. M., Liu, S., & Yang, J. K. (2020). Gender Differences in Patients With COVID-19: Focus on Severity and Mortality. Frontiers in Public Health, 8(April), 1–6. https://doi.org/10.3389/fpubh.2020.00152

Kautzky-Willer, A. (2021). Does diabetes mellitus mitigate the gender gap in COVID-19 mortality? European Journal of Endocrinology, 185(5), C13–C17. https://doi.org/10.1530/EJE-21-0721

Kemenkes, R. (2022). Situasi Covid-19. https://www.kemkes.go.id/

Kumar, A., Gupta, R., Ghosh, A., & Misra, A. (2020). Diabetes in COVID-19. January. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195120/pdf/main.pdf

Lazarus, G., Audrey, J., Wangsaputra, V. K., Tamara, A., & Al, E. (2020). High admission blood glucose independently predicts poor prognosis in COVID-19 patients: A systematic review and dose-response meta-analysis. January.

Li, F., Cai, Y., Gao, C., Zhou, L., Chen, R., Zhang, K., Li, W., Zhang, R., Zhang, X., Wang, D., Liu, Y., & Tao, L. (2021). Effects of Diabetes and Blood Glucose on COVID-19 Mortality A Retrospective Observational Study. MedRxiv, 2021.01.21.20202119. https://doi.org/10.1101/2021.01.21.20202119%0Ahttps://medrxiv.org/cgi/content/short/2021.01.21.20202119

Lim, S., Bae, J. H., Kwon, H. S., & Nauck, M. A. (2021). COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nature Reviews Endocrinology, 17(1), 11–30. https://doi.org/10.1038/s41574-020-00435-4

Mahamat-Saleh, Y., Fiolet, T., Rebeaud, M. E., Mulot, M., Guihur, A., El Fatouhi, D., Laouali, N., Peiffer-Smadja, N., Aune, D., & Severi, G. (2021). Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: A systematic review and meta-analysis of observational studies. BMJ Open, 11(10). https://doi.org/10.1136/bmjopen-2021-052777

Mahardhika, G. S. (2021). Hyperglycemia Induced by COVID-19 with and without Present Diabetes: A Systematic Review. KELUWIH: Jurnal Kesehatan Dan Kedokteran, 2(2), 64–74. https://doi.org/10.24123/kesdok.v2i2.4431

Myers, A. K., Kim, T. S., Zhu, X., Liu, Y., Qiu, M., & Pekmezaris, R. (2021). Predictors of mortality in a multiracial urban cohort of persons with type 2 diabetes and novel coronavirus 19. Journal of Diabetes, 13(5), 430–438. https://doi.org/10.1111/1753-0407.13158

Nguyen, N. T., Chinn, J., de Ferrante, M., Kirby, K. A., Hohmann, S. F., & Amin, A. (2021). Male gender is a predictor of higher mortality in hospitalized adults with COVID-19. PLoS ONE, 16(7 July), 1–6. https://doi.org/10.1371/journal.pone.0254066

Osi, A. A., Abdu, M., Muhammad, U., Ibrahim, A., Isma’il, L. A., Suleiman, A. A., Abdulkadir, H. S., Sada, S. S., Dikko, H. G., & Ringim, M. Z. (2020). A classification approach for predicting COVID-19 Patient’s survival outcome with machine learning techniques. MedRxiv. https://doi.org/10.1101/2020.08.02.20129767

Purnomo, Y. (2018). Potensi toleransi oral glukosa ekstrak biji kedelai (Glycine max), rimpang jahe (Zingiber officinale) dan kombinasinya pada tikus model diabetes. EJKI, 7(1), 45–50. http://riset.unisma.ac.id/index.php/jk

Rahayu, L. A. D., Admiyanti, J. C., Khalda, Y. I., Ahda, F. R., Agistany, N. F. F., Setiawati, S., Shofiyanti, N. I., & Warnaini, C. (2021). Hipertensi, Diabetes Mellitus, Dan Obesitas Sebagai Faktor Komorbiditas Utama Terhadap Mortalitas Pasien Covid-19: Sebuah Studi Literatur. JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia, 9(1), 90–97. https://doi.org/10.53366/jimki.v9i1.342

Shauly-Aharonov, M., Shafrir, A., Paltiel, O., Calderon-Margalit, R., Safadi, R., Bicher, R., Barenholz-Goultschin, O., & Stokar, J. (2021). Both high and low pre-infection glucose levels associated with increased risk for severe COVID-19: New insights from a population-based study. PLoS ONE, 16(7 July), 1–11. https://doi.org/10.1371/journal.pone.0254847

Varghese, E., Samuel, S. M., Liskova, A., Kubatka, P., & Büsselberg, D. (2021). Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of MAU etformin: Inordertomaintaincon intervention and the scientific basis of drug repurposing. PLoS Pathogens, 17(6), 1–20. https://doi.org/10.1371/journal.ppat.1009634

Wang, W., Shen, M., Tao, Y., Fairley, C. K., Zhong, Q., Li, Z., Chen, H., Ong, J. J., Zhang, D., Zhang, K., Xing, N., Guo, H., Qin, E., Guan, X., Yang, F., Zhang, S., Zhang, L., & He, K. (2021). Elevated glucose level leads to rapid COVID-19 progression and high fatality. BMC Pulmonary Medicine, 21(1), 1–13. https://doi.org/10.1186/s12890-021-01413-w

Wu, J., Huang, J., Zhu, G., Wang, Q., Lv, Q., Huang, Y., Yu, Y., Si, X., Yi, H., Wang, C., Liu, Y., Xiao, H., Zhou, Q., Liu, X., Yang, D., Guan, X., Li, Y., Peng, S., Sung, J., & Xiao, H. (2020). Elevation of blood glucose level predicts worse outcomes in hospitalized patients with COVID-19: A retrospective cohort study. BMJ Open Diabetes Research and Care, 8(1), 1–7. https://doi.org/10.1136/bmjdrc-2020-001476

Xiao, F., Zhou, Y., Zhang, M., Chen, D., Peng, S., Tang, H., Li, L., Tang, C., Liu, J., Li, B., & Zhou, H. (2021). Hyperglycemia and blood glucose deterioration are risk factors for severe COVIDâ€19 with diabetes: a twoâ€center cohort study. Journal of Medical Virology. https://doi.org/10.1002/jmv.27556

Zhu, L., She, Z.-G., Cheng, S., & Qin, J.-J. (2020). Association of Blood Glucose Control and Outcomes.pdf. Cell Metabolism, 31(June), 1068–1077.

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Published

2022-08-22

Issue

Vol. 19 No. 2: September 2022

Section

Clinical Pharmacy

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