OPTIMASI FORMULA MATRIK PATCH MUKOADHESIF EKSTRAK DAUN SIRIH (Piper betle L.) MENGGUNAKAN MENTOL DAN PEG 400 SEBAGAI PERMEATION ENHANCER DAN PLASTICIZER

Authors

  • Eka Indra Setyawan
  • IGN Agung Dewantara
  • IMD Dwi Putra

DOI:

https://doi.org/10.12928/mf.v11i2.1872

Keywords:

ekstrak daun sirih, mentol, PEG 400, mukoadhesif matrik patch

Abstract

Daun sirih (Piper betle L) adalah tanaman obat tradisional yang secara empirik dimanfaatkan masyarakat untuk pengobatan antiinflamasi gusi. Penelitian ini bertujuan untuk memformulasi ekstrak etanol daun sirih ke dalam sistem penghantaran obat baru yakni patch mukoadhesif. Ekstrak daun sirih sebagai bahan aktif dibuat dengan teknik maserasi sedangkan formulasi patch dibuat menggunakan sistem matrix controlled. Bahan tambahan yang dipergunakan dalam pembuatan patch antara lain; hidroksipropil metilselulosa, polietilenglikol 400, dan mentol. Komposisi pemakaian polietilenglikol 400 dan mentol dalam formula ditentukan dengan menggunakan metode simplex lattice design. Evaluasi matrik patch meliputi; bobot matrik patch, ketebalan matrik patch, folding endurance dan loss on drying. Hasil penelitian memperlihatkan bobot matrik berkisar antara 0,510 - 2,837 g, tebal matrik antara 0,28 - 1,00 mm, folding endurance antara 60 - > 500 lipatan dan loss on drying antara 0,063% - 0,099%. Formula optimal dihasilkan oleh kombinasi mentol dan PEG 400 dengan perbandingan 2:0 atau dengan nilai desirability 0,931.

 

 

 

Vol.11 No.2 September 2014

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Published

2014-09-01

Issue

Vol. 11 No. 2: September 2014

Section

Pharmaceutical & Technology

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