The gastroprotective effects of canna edulis ker. tuber starch on peptic ulcer and the histopathological profile of rat stomach

Robby Najini, Moch Saiful Bachri, Sapto Yuliani


Ganyong rhizome (Canna edulis Ker.) empirically use for treating gastritis (peptic ulcers). Ganyong rhizome contains carbohydrates and flavonoid that can reduce inflammation in the gastric tissues and againsts free radicals that are contributing to the pathogenesis of peptic ulcers. This research aims to know the gastroprotective effect of ganyong rhizome on white female rats, Wistar strain, which were given alcohol (ethanol 96%) by dose 1 ml/200gBB and measuring the total flavonoids content in ganyong rhizome. This research is Post Test Only Control Group Design, using 30 rats, weight 150-200 g, age 6-8 weeks, health condition. It is divided into six groups. Group I (normal) were fed and watered only, Group II (control) were given a CMC-Na 0,5%, Group III-V were given a suspension of ganyong rhizome starch (SGRS) with each doses 250, 500, and 1000 mg/kgBB, then Group VI were given a sucralfate dose 360 mg/kgBB. Rats were given oral treatment for 14 days. An hour after the treatment on 14th day, the whole groups unless the group I were given ethanol 96% 1 ml/200gBB orally. Twenty four hours later the rats were sacrificed, dissected and taken its gastric for further analyzed the number of ulcers as well as the description of histopathology of the gastric. The results showed that ganyong rhizome starch can decrease the index ulcer and increase the protection ratio value to the control group with results of doses SGRS 250, 500, 1000 mg/kgBB sequentially i.e., 12,5; 50; and 75%. The description of histopathology also showed significant improvement of gastric tissue at a dose of 1000 mg/kgBB. In addition, on TLC-Densitometri test also obtained the total flavonoid compound in ganyong rhizome is 112,49 ± 7,97 ppm. Conclusions of this research are that the ganyong rhizome positive contains flavonoid and it has gastroprotective effect by decreasing the number of index ulcer, increasing the protection ratio value, and improving the histopathology of gastric tissue which had given alcohol.


ganyong rhizome starch, peptic ulcer, gastroprotective, total flavonoid

Full Text:



Abdel-Raheem, I. T., 2010, Gastroprotective effect of rutin against indomethacin-induced ulcers in rats, Basic and Clinical Pharmacology and Toxicology, 742-750.

Chang, C.C., Yang., M.H., Wem, H.M., & Chern, J.C., 2002, Estimation of Total Flavonoid Content in Propolis by Two Comlpementary Colorimetric Methods, Journal of Food and Drug Analysis, 10(3): 178-182.

de Lira Mota, K. S., Dias, G. E., Pinto, M. E., Lima, C. A., Ferreira, A. L., Brito, A. R., 2009, Flavonoids with Gastroprotective Activity, Molecules, 979-1012.

Falcao, H. d., Leite, J. A., Barbosa-Filho, J. M., de Athayde-Filho, P. F., de Oliveira Chaves, M. C., Moura, M. D., 2008, Gastric and duodenal antiulcer activity of alkaloids : a review. Molecules, 3198-3223.

Guyton, A.C., and Hall, J.E., 2008, Buku Ajar Fisiologi Kedokteran, edisi 11, EGC Penerbit Buku Kedokteran, Jakarta.

Hariana, A., 2013, 262 Tumbuhan Obat dan Khasiatnya, Penebar Swadaya, Jakarta.

Kim, S. C., Byun, S. H., and Yang, C. H., 2004, Cytoprotective effects of glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage), Toxicology, 197(3): 239-251.

Kusbandari, A. and Lukitaningsih, E., 2013, Analisis kandungan karbohidrat dan nilai indeks glisemik serta aktivitas anti ulser dan anti kolesterol umbi ganyong (Canna Edulis Ker.), Tesis, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta.

Lestari, P., 2008, Uji efek antiulcer perasan umbi ganyong (Canna edulis Ker.) pada tikus putih jantan galur wistar, Skripsi, Fakultas Farmasi, Universitas Muhammadiyah Surakarta.

Lestari, W.P., 2004, Infusa Umbi Ganyong (Canna edulis Ker): Pengaruhnya terhadap ulkus peptik tikus jantan karena salisilat dan profil kromatografi lapis tipisnya, Skripsi, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta.

Liu, C.F., Lin, C.C., Lin, M.H., Lin, Y.S., & Lin, S.C., 2002, Cytoprotection by propolis ethanol extract of acute absolute ethanol-induced gastric mucosal lesions, The American Journal of Chinese Medicine, 30(2-3): 245-254.

Maslachah, L., Sugihartini, R., and Ankestri, H., 2008, Description of white rat (Rattus norvegicus) intestine that was given juice of noni (Morinda citrifolia) and high fatty diet, Veterinaria Medika, 1(3): 103-108.

Miller, A.L., 2003, Antioxidant Flavonoids: Structure, Function and Clinical Usage, Alternative Medicine Review, 1(2): 103-111.

Mishra, T., Das, AP., & Sen, A., 2011, Phytochemical screening and in-vitro antioxidant profiling of solvent fractions of Canna edulis Ker Gawler, Free Radicals and Antioxidants, 2(1):13-20.

Pastrana-Bonilla, E., Akoh, C.C., Sellappan, S., and Krewer, G., 2003, Phenolic content and antioxidant capacity of muscadine grapes, Journal of Agricultural and Food Chemistry, 51(18): 5497-5503.

Pertiwi, R. and Bachri, MS., 2016, Efek gastroprotektor ekstrak etanol umbi garut (Maranta arundinacea L.) terhadap indeks tukak lambung, rasio proteksi, ekspresi protein COX-2 dan gambaran histopatologis lambung pada tikus model tukak lambung, Tesis, Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakarta.

Pospos, N.S., 2002, Bukti gambar, etanol merusak sel hati dan pengaruhnya terhadap konsentrasi ATP intraseluler, Medika, 1(27): 17-20.

Rajashekhara, N., Ashok, B. K., Parmeshwar, Sharma. P., Ravishankar, B., 2014, The evaluation of anti-ulcerogenic effect of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.) on pyloric ligated rats, An International Quartely Journal of Research in Ayurveda, 35(2): 191-196.

Saptarini, N.M., Suryasaputra, D., & Saepulhak, A.M., 2011, Analisis rasio proteksi antiulser sari buah pepino (Solanum muricaum Aiton) menggunakan tikus sebagai model hewan coba, Majalah Obat Tradisional, 16 (2): 75-80.

Turner, JR., 2010, The Gastrointestinal Tract, In Robbins and Cotran: Pathologic Basis of Disease, 8th edition, Philadelphia, Saunders Elsevier.

Wardhani, L.K., and Sulistyani, N., 2012, Antibacterial activity test of ethyl acetate extract of binahong leaf (Anredera scandens (L.) Moq.) against Shigella flexneri with the profile of thin layer chromatography, Jurnal Ilmiah Kefarmasian, 2(1): 1-16.

Wibisono, A.S, 2012, Keracunan alkohol beracun, Majalah Kedokteran Terapi Intensif, Laporan Kasus, 2(2), Jakarta.

Yanwirasti, 2008, Langkah-langkah Pokok Penelitian Biomedik, Fakultas Kedokteran Universitas Andalas, Padang.

Yuangsoi, B., Jintasataporn, O., Areechon, N. and Tabthipwon, P., 2008, Validated TLC-densitometric analysis for determination of carotenoids in fancy carp (Cyprinus carpio) serum and the application for pharmacokinetic parameter assessment, Songklanakarin J. Sci. Technol., 30(6), 693-700.



  • There are currently no refbacks.

Copyright (c) 2018 Pharmaciana

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


Pharmaciana indexed by:

Google ScholarDirectory of Open Access JournalIndonesian Scientific Journal Database (ISJD)Indonesian Publication Index (IPI)CrossrefBielefeld Academic Search Engine (BASE)Sherpa RomeoOpen Academic Journal Index (OAJI)





Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.