Neuropharmacological Activity of Nut Grass (Cyperus Rotundus L.) Rhizome Fraction

Lusi Putri Dwita, Ema Dewanti, Vera Ladeska, Sediarso Sediarso, Adnan Muntashir, Ulfa Safni, Rahma Wulan Sari

Abstract


Research in the area of herbal neuropharmacological effects has increased markedly over the past decades. This research was aimed to further investigate neuropharmacological properties of Cyperus rotundus rhizomes fraction by measuring hypnotic-siccative and anticonvulsant activities. The exploratory behavior test was performed using Hole Board method while motor coordination was assessed using Rotarod Test. The result showed that the 70% ethanol fraction of Cyperus rotundus rhizome in has significant (p <0,05) neuropharmacological activities. All three fractions tested (ethanol, ethyl acetate, and n-hexane), the ethanol fraction showed the best hypnotic-sedative and anticonvulsant activities. Ethanol Cyperus rotundus rhizome fraction could decrease the duration of HLE equal to sodium valproate and potentiated the phenobarbital-induced sleep by decreasing the onset and prolonging the duration of sleep. The highest dose of 70% ethanol fraction of Cyperus rotundus rhizome (356.7 mg/kg) showed the best anxiolytic activity comparable to diazepam (p> 0.05). In conclusion, Teki ladang (Cyperus rotundus) rhizome appeared as potent neuropharmacological drug candidate with abilities comparable to synthetics drugs. 


Keywords


hypnotic, anxiolytics, anticonvulsant, Cyperus rotundus, rhizome

Full Text:

PDF

References


Aguirre-Hernández, E., González-Trujano, M.E., Terrazas, T., Santoyo, J.H., and Guevara-Fefer, P. 2016. Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation, Salud Mental, 39(1): 37–46.

Ahmad, M., MahayRookh, Rehman, A.B., Muhammad, N., Amber, Younus, M., and Wazir, A. 2014. Pharmacological activities of Cyperus rotundus Linn , 27(6): 2241–2246.

Ajao, M.Y., and Akindele, A.J. 2013. Anxiolytic and sedative properties of hydroethanolic extract of Telfairia occidentalis leaves in mice, Brazilian Journal of Pharmacognosy, Elsevier, 23(2): 301–309.

Arenas, M.C., Daza-Losada, M., Vidal-Infer, A., Aguilar, M.A., Miñarro, J., and Rodríguez-Arias, M. 2014. Capacity of novelty-induced locomotor activity and the hole-board test to predict sensitivity to the conditioned rewarding effects of cocaine, Physiology and Behavior. Elsevier B.V, 133: 152–160.

Biradar, S., Kangralkar, V.A., Mandavkar, Y., Thakur, M., and Chougule, N. 2010. Anti ­ Inflammatory, Anti ­ Arthritic , Analgesic and Anticonvulsant Activity of Cyperus Essential Oils, 2(4): 9–12.

Brown, G.R., and Nemes, C. 2008. The exploratory behaviour of rats in the hole-board apparatus: Is head-dipping a valid measure of neophilia?, Behavioural Processes, 78(3): 442–448.

Brunton, L., Chabner, B., and Knollman, B. 2013. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Journal of Chemical Information and Modeling.

Castel-Branco, M.M., Alves, G.L., Figueiredo, I.V., Falcao, A.C., and Caramona, M.M. 2009. The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs, Methods and Findings in Experimental and Clinical Pharmacology, 31(2):101.

Chouksey, D., Upmanyu, N., and Pawar, R. S. 2013. Central nervous system activity of Illicium verum fruit extracts, Asian Pacific Journal of Tropical Medicine. Hainan Medical College, 6(11): 869–875.

Doukkali, Z., Taghzouti, K., Bouidida, E.H., Nadjmouddine, M., Cherrah, Y., and Alaoui, K. 2015. Evaluation of anxiolytic activity of methanolic extract of Urtica urens in a mice model, Behavioral and Brain Functions, 11(1): 1–5.

Du, X.M., Sun, N.Y., Takizawa, N., Guo, Y.T., and Shoyama, Y. 2002. Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana, Phytotherapy Research, 16(3): 261–263.

Katzung, B. G. and Trevor, A. 2015. Chemotherapeutic Drugs, Basic and Clinical Pharmacology.

Krishna, S., and Renu, S. 2013. Isolation and Identification of Flavonoids From Cyperus Rotundus Linn. in Vivo and in Vitro, Journal of Drug Delivery & Therapeutics, 3(2): 109–113.

Mudium, R., and Kolasani, B. 2014. Anticonvulsant effect of hydroalcoholic seed extract of croton tiglium in rats and mice, Journal of Clinical and Diagnostic Research, 8(3): 24–26.

Saki, K., Bahmani, M., and Rafieian-Kopaei, M. 2014. The effect of most important medicinal plants on two importnt psychiatric disorders (anxiety and depression)-a review, Asian Pacific Journal of Tropical Medicine, 7(S1): S34–S42.

Venkatanarayana, N., Basha, G., Pokala, N., Jayasree, T., John, P., and Nagesh, C. 2013. Journal of Chemical and Pharmaceutical Research, 5(9): 60-64 Research Article Evaluation of anticonvulsant activity of ethanolic extract of Zingiber officinale in Swiss albino rats, 5(9): 60–64.

Yudistyawan, H.F. 2013. Efek ekstrak umbi rumput teki (Cyperus rotundus L) sebagai antipiretik pada tikus wistar jantan yang diinduksi vaksin DPT-Hb. Available at: http://repository.unej.ac.id/handle/123456789/3653.




DOI: http://dx.doi.org/10.12928/pharmaciana.v8i2.8938

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Lusi Putri Dwita, Ema Dewanti, Vera Ladeska, Sediarso Sediarso, Adnan Muntashir, Ulfa Safni, Rahma Wulan Sari

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


 
Pharmaciana
ISSN Print: 2088-4559 | ISSN Online: 2477-0256
Website: http://journal.uad.ac.id/index.php/PHARMACIANA
Office: Faculty of  Pharmacy, Universitas Ahmad Dahlan
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia
Kode pos 55164
Email: pharmaciana@pharm.uad.ac.id