IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009-JANUARI 2010

Abstract

The potensial drug interaction is potential action of a drug that changed or
influced by other drugs concurrenly. Drug interactions are defined as a phenomenon
that occurs when the pharmacokinetic effect of a drug changes due to other drug
delivery. Drug interactions could cause advers drug reactions when the potential for a
previously unknown interaction. The purpose of this study is to identify potential drug
interactions in patient hospitalized in the Prof. Dr. Margono Soekarjo Purwokerto
Hospital. The research method was an observasional retrospective study (November
2009-January 2010) by using descriptive methods for the data analysis.The result
showed that the potential drug interactions in the hospitalized patients in Prof. Dr.
Margono Soekarjo Hospital is 56,76% (n= 259). Based on the significance categories
which proposed by Tatro (2006): a potential drug interaction with significance
category 1 in ward patients in prof. Dr. Margono Soekarjo Hospital is 16,67%. The
drug used thet known potential interaction, especially in the category of significance 1
should be tailored to the patient’s need, risk and benefit, and have made efforts to
optimize it.