The effect of concentration variation of ethanolic extract from potato peels (Solanum tuberosum L.) on the physical properties and antibacterial activity of gels against Propionibacterium acnes

Dewi Rashati, Mikhania Cristiningtyas Eryani

Abstract


Gel is a semisolid dosage form that consumers prefer because of its cool sensation. This research aimed to identify the effect of different concentrations of ethanolic extract from potato peels on the physical properties and the antibacterial activities of the resultant gels against Propionibacterium acnes. The gel was prepared with three formulas using a variety of potato peel concentrations, namely 50%, 60% and 70%. Its physical properties were analyzed based on organoleptic observation, homogeneity, pH, and spreadability. The results showed that the ethanolic extract of potato peels affected the color and viscosity of the gel. However, no effects were detected on shape, smell, pH, and spreadability. All formulas showed strong inhibitory capacity against Propionibacterium acnes.


Keywords


acne; Propionibacterium acnes; gel; potato

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References


Arikumalasari, J., Dewantara, I., dan Wijayanti, N., 2013, Optimasi HPMC sebagai Gelling Agent dalam Formula Gel Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.), Jurnal Farmasi Udayana, 2 (3), 145 – 152.

Mayuna, N.E., 2013, Pengaruh Pemanfaatan Madu dan Air Perasan Jeruk Nipis Terhadap Penyembuhan Jerawat, Skripsi, Universitas Negeri Padang.

Movita, T, 2013, Acne Vulgaris, CDK-203, 40 (4), 269 – 272.

Departemen Kesehatan Republik Indonesia. 1995. Farmakope Indonesia. Edisi IV

Miratunnisa, Mulqie L., Hajar, S, 2015, Uji Aktifitas Antibakteri Ekstrak Etanol Kulit Kentang (Solanum Tuberosum L.) terhadap Propinibacterium, Prosiding Penelitian SpeSIA Unisba, Bandung, 510-516.

Mappa, T., Edy, H.J., Kojong, N, 2013, Formulasi Gel Ekstrak Daun Sasaladahan (Peperomia pellucida (L.) H.B.K) dan Uji Efektivitasnya Terhadap Luka Bakar pada Kelinci (Oryctolagus Cuniculus), Pharmacon, 2 (2), 49 – 55.

Kumesan, Y.A.N, Paulina, V.Y.Y, Supriati, H.S, 2013, Formulasidan Uji Aktivitas Gel Antijerawat Ekstrak Umbi Bakung (Crinium Asiaticum L.) Terhadap Bakteri Staphylococcus Aureus Secara In Vitro, Pharmacon, 2 (2), 18-26.

Dwiastuti, Rini, 2010, Pengaruh Penambahan CMC (Carboxymethyl Cellulose) Sebagai Gelling Agent dan Propilen Glikol Sebagai Humektan dalam Sediaan Gel Sunscreen Ekstrak Kering Polifenol Teh Hijau (Camellia sinensis L.), Jurnal Penelitian, 13 (2), 227-240.

Garg, A., Aggarwal, D., Garg, S., Singla, A., 2002, Spreading of Semisolid Formulations : An Update, Pharmaceutical Technology, 84 – 105.

Rowe, R.C., Sheskey, P., Quinn, M.E., 2006, Handbook of Pharmaceutical Excipients, Edisi 6. London, Pharmaceutical Press, 438.




DOI: http://dx.doi.org/10.12928/pharmaciana.v8i2.8395

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Pharmaciana
ISSN Print: 2088-4559 | ISSN Online: 2477-0256
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