In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia

Authors

  • Sri Utami Faculty of Medicine, YARSI University
  • Sonny Pamuji Laksono Faculty of Medicine, YARSI University
  • Qomariyah Romadhiyani Sachrowardi Faculty of Medicine, YARSI University
  • Dewi Nurul Mustaqimah Faculty of Medicine, YARSI University
  • Susi Endrini Faculty of Medicine, YARSI University
  • Ndaru Andri Damayanti Faculty of Medicine, YARSI University
  • Said Nafik Directorate General of Intellectual Property, Ministry of Law and Human Rights, Jl. H.R. Rasuna Said, Kuningan, Jakarta Selatan. Indonesia.
  • Betharie Cendera Arrahmani Faculty of Business and Engineering, University of Applied Sciences Würzburg-Schweinfurt, Ignaz-Schön Str 11, 97421 Schweinfurt, Germany.
  • Hanna Sari Widya Kusuma Aretha Medika Utama, Biomolecular and Biomedical Research Center
  • Wahyu Widowati Faculty of Medicine, Maranatha Christian University

DOI:

https://doi.org/10.12928/pharmaciana.v11i2.20110

Keywords:

antidiabetic, antioxidant, Garcinia picrorrhiza, xanthone

Abstract

Diabetes mellitus (DM) is a disease that can be identified by high levels of blood glucose. Garcinia plants have been widely used for many traditional medicines as antioxidant, anticancer, antidiabetics, and antiinflammation. The antioxidant and antidiabetic activities of (Garcinia picrorrhiza Miq.) or sesoot fruit extract were evaluated in this study and compared with xanthone. The antioxidant and antidiabetic of ethanolic ripe sesoot (G. picrorrhiza Miq.) fruit extract (GpKar) was evaluated by (ABTS) reducing activity, α-glucosidase, β-glucosidase, and α-amylase inhibitor activity. GpKar showed higher ABTS-reducing activity (IC50 = 49.30 µg/mL) than xanthone (IC50 = 404.30 µg/mL). GpKar showed IC50 = 109.32 µg/mL for α-glucosidase inhibitory activity, while xanthones had a better activity (IC50 = 33.97 µg/mL). GpKar also showed lower α-amylase inhibitory activity and  β-glucosidase (IC50 = 126.01 and 9432.09 µg/mL) compared to xanthone (IC50 = 44.32 and 405.03 µg/mL, respectively). The compounds of GpKar are proven to have antioxidant and antidiabetic activities. Therefore, it will be industrially relevant to develop a natural medicine for decreasing DM risk, thus evaluating the antioxidant and antidiabetic effect of G. picrorrhiza by a pre-clinic study is needed.

References

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Published

2021-07-30

Issue

Vol. 11 No. 2 (2021): Pharmaciana

Section

Biology Pharmacy

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