Development of black cumin seed oil (Nigella sativa L.) SNEDDS into solid-SNEDDS and its characterization

Rodhia Ulfa, Dwi Utami, Iis Wahyuningsih

Abstract


Black cumin seed oil (MBJH) (Nigella sativa L.) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. The liquid SNEDDS (Self-nanoemulsifying drug delivery system) of MBJH as an alternative formulation. However, the disadvantage of liquid-SNEDDS of MJBH was the interaction between the active ingredients with soft gelatin capsules. Hence, this study proposed to develop solid-SNEDDS as a new formulation of MBJH. Solid-SNEDDS of MBJH was prepared from liquid-SEDDS of MBJH by adsorption to solid carrier method, consisting of aerosil and crospovidone as the adsorbent. The characterization of S-SNEDDS was determined by emulsification time and percent transmittance. Micromeritics properties of S-SNEDDS such as the angle of repose, bulk and tap density parameter, compressibility index, and Hausner ratio were measured  before and after stored in stress condition (40 ̊ C ± 2 ̊ C and relative humidity of 75% ± 5% for 14 days). The result showed S-SNEDDS of MBJH with aerosil absorbent had better S-SNEDDS performance in both characteristics and micromeritics properties under stress conditions than crospovidone absorbent. In conclusion, the s-SNEDDS of black cumin oil by solid aerosil carrier method is promising for future research development of S-SNEDDS dosage form.


Keywords


black cumin seed oil; SNEDDS; S-SNEDDS; characterization; micromeritics properties

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References


Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A. K., Siddique, N. A., Damanhouri, Z. A., & Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337–352. https://doi.org/10.1016/S2221-1691(13)60075-1

Alkotzer. Y.I., Grzegorzewski. F., Belausov. E., Zelinger. E., and Mechrez. G., (2019). In situ interfacial surface modification of hydrophilic silica nanoparticles by two organosilanes leading to stable Pickering emulsions, Royal Society of Chemistry advances, 9, 39611-39621, https://doi.org/10.1039/C9RA07597F

Anlar. H.G., and Bacanli. M.(2020). Thymoquinone: The active compound of black seed (Nigella sativa). Pathology : Oxidative stress and Dietary antioxidant, 369-378. https://doi.org/10.1016/B978-0-12-815972-9.00035-4

Alwadei, M., Kazi, M., & Alanazi, F. K. (2019). Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone. Saudi Pharmaceutical Journal, 27(6), 866–876. https://doi.org/10.1016/j.jsps.2019.05.008

Chavda, H., Patel, J., Chavada, G., Dave, S., Patel, A., & Patel, C. (2013). Self-Nanoemulsifying Powder of Isotretinoin: Preparation and Characterization. Journal of Powder Technology, 2013, 1–9. https://doi.org/10.1155/2013/108569

Heshmati, N., Cheng, X., Eisenbrand, G., & Fricker, G. (2013). Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats. Journal of Pharmaceutical Sciences, 102(10), 3792–3799. https://doi.org/10.1002/jps.23696

ICH. (2003). Stability Testing of New Drug Substances and Products Q1A (R2). ICH. https://www.ema.europa.eu/en/documents/scientific-guideline/ich-q-1-r2-stability-testing-new-drug-substances-products-step-5_en.pdf

Iswari, T. . (2016). Optimasi Formula Self Nano Emulsifying Drug Delivery System (SNEDDS) MBJH dengan Surfaktan Tween 80 dan Ko-surfaktan Gliserol

Gupta, S., Kesarla. R., Omni. A. (2013). Formulation to Improved the bioavailabilty of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharmaceutics. http://dx.doi.org/10.1155/2013/848043

Katteboina, S., Chandrasekhar, P., & Balaji, S. (2019). Approaches for the development of solid self-emulsifying drug delivery systems and dosage forms. Asian Journal of Pharmaceutical Sciences, 240–253

Kuruvila, F. S., Mathew, F., & Kuppuswamy, S. (2017). Solid Self Nanoemulsifying drug delivery system (Snedds ) Devolopment , Applications and Future Perspective : A Review. Indo American Journal of Pharmaceutical Sciences, 4(03), 651–669

Nasr, A., Gardouh, A., & Ghorab, M. (2016). Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: Design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics, 8(3). https://doi.org/10.3390/pharmaceutics8030020

Niazi, S. K. (2020). Stability Testing of New Drug Substances and Products. Handbook of Pharmaceutical Manufacturing Formulations, June 2001, 31–40. https://doi.org/10.1201/9781420048452-7

Obitte, N. C., Ofokansi, K. C., & Kenechukwu, F. C. (2014). Development and evaluation of novel self-nanoemulsifying drug delivery systems based on a homolipid fromapra hircus and Its admixtures with melon oil for the delivery of indo cmethacin. 2014. https://doi.org/10.1155/2014/340486

Patel, J. & Aneja, K. & Tiwari, R. (2010). review on bioavailability and bioequivalence trials and its necessity. International Journal of Pharmacy and Pharmaceutical Sciences, 2, 1–8

Reddy, M. S. (2018). Formulation and In Vitro Characterization of Solid-self Nanoemulsifying Drug Delivery System of Atorvastatin Calcium. Asian Journal of Pharmaceutics, 11(4), 991–999. http://www.asiapharmaceutics.info/index.php/ajp/article/view/1771

Salmani, J. M. M., Asghar, S., Lv, H., & Zhou, J. (2014). Aqueous solubility and degradation kinetics of the phytochemical anticancer thymoquinone; probing the effects of solvents, pH and light. Molecules, 19(5), 5925–5939. https://doi.org/10.3390/molecules19055925

Santoso, S. D., & Suryanto, I. (2017). Komparasi Efek Pemberian Minyak Jintan Hitam (Nigella sativa) Dengan Minyak Zaitun (Olea europea) Terhadap Penurunan Glukosa Darah Pada Mencit (Mus musculus) Strain Balb/c. Jurnal Sain Health, 1(1), 36. https://doi.org/10.51804/jsh.v1i1.76.36-42

Shanmugam, S., Baskaran, R., Balakrishnan, P., Thapa, P., Yong, C. S., & Yoo, B. K. (2011a). Solid self-nanoemulsifying drug delivery system (S-SNEDDS) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein. European Journal of Pharmaceutics and Biopharmaceutics, 79(2), 250–257. https://doi.org/10.1016/j.ejpb.2011.04.012

Sunitha Reddy, M., & Sowjanya, N. (2015). Formulation and in-vitro characterization of solid self nanoemulsifying drug delivery system (S-SNEDDS) of Simvastatin. Journal of Pharmaceutical Sciences and Research, 7(1), 40–48

Umeyor, C., Attama, A., Uronnachi, E., Kenechukwu, F., Nwakile, C., Nzekwe, I., Okoye, E., & Esimone, C. (2016). Formulation design and in vitro physicochemical characterization of surface modified self-nanoemulsifying formulations (SNEFs) of gentamicin. International Journal of Pharmaceutics, 497(1–2), 161–198. https://doi.org/10.1016/j.ijpharm.2015.10.033

Waddington, F., Naunton, M., Kyle, G., Thomas, J., Cooper, G., & Waddington, A. (n.d.). A systematic review of community pharmacist therapeutic knowledge of dietary supplements. International Journal of Clinical Pharmacy. https://doi.org/10.1007/s11096-015-0092-5

Wahyuningsih, I., & Putranti, W. (2015). Optimasi perbandingan tween 80 dan polietilenglikol 400 pada formula self nanoemulsifying drug delivery system (SNEDDS) minyak biji jinten hitam. Pharmacy, 12(02), 223–241

Yi, T., Wan, J., Xu, H., & Yang, X. (2008). A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics, 70(2), 439–444. https://doi.org/10.1016/j.ejpb.2008.05.001

Yoo, J. H., Shanmugam, S., Thapa, P., Lee, E. S., Balakrishnan, P., Baskaran, R., Yoon, S. K., Choi, H. G., Yong, C. S., Yoo, B. K., & Han, K. (2010). Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Archives of Pharmacal Research, 33(3), 417–426. https://doi.org/10.1007/s12272-010-0311-5




DOI: http://dx.doi.org/10.12928/pharmaciana.v11i2.18230

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