UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO

Authors

  • Laela Hayu Nurani
  • Dwi Utami
  • Wahyu Widyaningsih
  • Iin Narwanti
  • Eti Nurwening
  • Jumina Jumina

DOI:

https://doi.org/10.12928/pharmaciana.v4i2.1575

Keywords:

Polymerization heme, (1)-N-(2-nitrobenzyl)-1, 10-phenantrolinium iodide, (1)-N- (4-nitrobenzyl)-1, choloroquin, malaria

Abstract

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10-
phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been
done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and
(1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme.
Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The
activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)-
1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium
iodide and chloroquine by successively are 0,571±0,071; 25,498±1,876 mg/mL. The result
showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the
heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10-
phenantrolinium iodide hadn’t the heme polymerization inhibitory activity.

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Published

2014-11-01

Issue

Vol. 4 No. 2 (2014): Pharmaciana

Section

Analytical Pharmacy and Medicinal Chemistry

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