Anti-inflammatory effects of avocado peels against inflammation induced by carrageenan in mice

Eko Aprilianto, Alexander Vito Harmoni Swantika Yuan, Claudia Darantika Pradita, Phebe Hendra

Abstract


The aim of this research is to investigate the anti-inflammatory activity of avocado peel against carrageenan-induced inflammation in mice. The group of mice that was used as a negative control group to test the anti-inflammatory activity of infusion and decoction (group I) were given aquadest, while the group for testing the activity of extract (group II) was given CMC-Na. The positive control group (group III) was given potassium diclofenac. Groups IV-VI were given avocado peel infusion with the following doses 667.5; 1335; and 2670 mg/kgBW respectively. Groups VII-IX were given avocado peel decoction with the same doses as the previous groups. Groups X-XII were given 830; 1670; and 3330 mg/kgBW of avocado peel extract respectively. The paw edema were measured using a digital caliper for 6 hours afterwards after carrageenan injection. There were a significant (p<0.05) reduction in paw edema at all doses of infusion, decoction, and extract of avocado peel. Based on the research, it can be concluded that the avocado peels have anti-inflammatory activities.


Keywords


avocado; peel; anti-inflammatory; carrageenan

Full Text:

PDF

References


Adeyemi, O.O., Okpo, S.O., Ogunti, O.O., 2002. Analgesic and anti-inflammatory effects of the aqueous extract of leaves of Persea Americana Mill ( Lauraceae), Fitoterapia, 73: 375-380.

Ardhie, A.M., 2011. Radikal Bebas dan Peran Antioksidan dalam Mencegah Penuaan, Medicinus, 24(1), 4-9.

Arukwe, U., Amadi, B., Duru, M., Agommo, E.N., Adindu, E.A., Odika, P.C., Lele, K.C., Egejuru, L., dan Anudike, J., 2012. Chemical Composition of Persea americana Leaf, Fruit and Seed, IJRRAS, 11(2): 346-349.

Boakye-Gyasi E,. Woode E., Ainooson, G.K., Obiri, D.D., Ansah, C., Duwejua, M., Donkoh, A., 2008. Anti-inflammatory and Antipyretic Effects of Ethanolic Extract of Palisota hirsuta K. Schum Roots, African Journal of Pharmacy and Pharmacology, 2 (9): 191-199.

Chamundeeswari, D., Vasantha, J., Gopalakrishnan, S., Sukumar, E., 2004. Anti-inflammatory and Antinociceptive Activities of Trewia polycarpa Roots, Fitoterapia, 75(8): 740-744.

Chaulya, N.C., Haldar, P.K., Mukherjee. A., 2012. Anti-inflammatory and Analgesic Activity of Methanol Extracts of Cyperus tegetum Roxb. Rhizome, Journal of PharmaSciTech, 1(2): 27-29.

Joshepine, O.O., and Ngozi, A.O., 2013. Analgesic Effect of The Aqueous Extract of Persea americana Mill (Lauraceae), Journal of Pharmaceutical and Allied Sciences, 10(3), 1887-1897.

Hendra, P., Fenty, Andreani, P.R., Pangestuti, B.M.E., Julianus, J., 2017. Evaluation of Antihyperlipidemic, Anti-inflammatory, and Analgesic Activities of Eurycoma longifolia in Animal Models. International Journal of Pharmacy and Pharmaceutical Sciences, 9(3): 166-169.

Karch, A.M., 2003. Focus on Nursing Pharmacology, 2nd Edition. New York, Lippincott Williams and Wilkins, 659-660.

Kosinska, A., Karamac, M., Estrella, I., Hernandez, T., Bartolome, B., dan Dykes, G.A., 2012. Phenolic Compound Profiles and Antioxidant Capacity of Persea americana Mill. Peels and Seeds of Two Varieties. Journal of Agriculture and Food Chemistry. 60(18): 4613-4619.

Kristanti, C.D., Simanjuntak, F.P.J., Dewi, N.K.P.A., Tianri, S.V., Hendra, P., 2017. Anti-inflammatory and Analgesic Activities of Avocado Seed (Persea Americana Mill.), Jurnal Farmasi Sains dan Komunitas, 14(2): 104-111.

Kyakulaga, AI.,H., Ogwang, P.E., Nannyonga, S., Nyafuono, J., and Tumuslime, R., 2012. Antipyretic and Analgesics Activities of Ethanolic Extract of Persea americana Mill. Seeds in Wistar Albino Rats. Africa Journal of Animal and Biomedical Sciences, 7(1): 19-23.

Malangngi, L.P., Sangi, M.S., dan Paendong J.J.E., 2012. Penentuan Kandungan Tanin dan Uji Aktivitas Antioksidan Ekstrak Biji Buah Alpukat (Persea americana Mill.). Jurnal Kimia FMIPA Unsrat, 1(1): 5-10.

Nguemfo, E.L., Dimo, T., Azebaze, A.G.B., Asongalem, E.A., Alaoui, K., Dongmo, A.B., Cherrah, Y., Kamtchouing, P., 2007. Anti-inflammatory and Anti-nociceptive Activities of The Stem Bark Extract from Allanblackia monticola STANER L.C. (Guttiferae), Journal of Ethnopharmacology, 114(3): 417-424.

Pourmourad, F., Hosseinimehr, S.J., Shahabimajd, N., 2006. Antioxidant Activity, Phenol and Flavonoid Contents of Some Selected Iranian Medicinal Plants, African Journal of Biotechnology, 5(11): 1142-1145.

Rodriguez-Carpena, J.G., Morcuende, D., Andrade, M.J., Kylli, P., dan Estevez, M., 2011. Avocado (Persea americana Mill.) Phenolics, in vitro Antioxidant and Antimicrobial Activities, and Inhibition of Lipid and Protein Oxidation in Porcine Patties. Journal of Agriculture and Food Chemistry, 59(10): 5625-5635.

Supriyatna, Febriyanti, R., Dewanto, Wijaya, I., dan Ferdiansyah, F., 2015. Fitoterapi Sistem Organ: Pandangan Dunia Barat terhadap Obat Herbal Global, Ed. 2, Cet. 2, CV Budi Utama, Yogyakarta, 223-224.

Tjandrawinata R.R., Djunarko, I., Fenty, Hendra, P., 2015. Anti-inflammation Effects of Bioactive Fraction DLBS0533 Containing Phaleria Macrocarpa and Nigella Sativa on Animal Model, Journal of Pharmacy and Pharmaceutical Sciences, 7(1): 408-411.

Vinha, A.F., Moreira, J., and Barreira, S.V.P., 2013. Physicochemical Parameters, Phytochemical Composition and Antioxidant Activity of the Algarvian Avocado (Persea americana Mill.), Journal of Agricultural Science, 5 (12): 100-109.




DOI: http://dx.doi.org/10.12928/pharmaciana.v9i2.13607

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Eko Aprilianto, Alexander Vito Harmoni Swantika Yuan, Claudia Darantika Pradita, Phebe Hendra

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


 
Pharmaciana
ISSN Print: 2088-4559 | ISSN Online: 2477-0256
Website: http://journal.uad.ac.id/index.php/PHARMACIANA
Office: Faculty of  Pharmacy, Universitas Ahmad Dahlan
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia
Kode pos 55164
Email: pharmaciana@pharm.uad.ac.id