KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010

Siti Rahmiati, Woro Supadmi

Abstract


Drug interactions are one of the Drug Related Problems (DRPs) that may affect
patient treatment outcomes. Hypertension occurs in approximately 10% to 81.5% of
hemodialysis patients. The purpose of this study was to determine the incidence of
antihypertensive drug interactions in hemodialysis patients in the inpatient wards PKU
Muhammadiyah Hospital of Yogyakarta period in 2010. This study descriptive design.
Data retrieved retrospectively. Data retrieval were done by taking all the data that
meet the criteria of existing research on the medical records of hemodialysis patients in
PKU Muhammadiyah Hospital of Yogyakarta who received antihypertensive with
above normal blood pressure (= 130/80 mmHg). Data were analyzed based on the
descriptive level of significance, onset, and severity. The results showed that there were
54.79% (40 patients) of 73 hemodialysis patients potentially experienced drug
interactions. Antihypertensive drugs most widely used in hemodialysis patients were
ACEI, CCB, and diuretics. Incidence of antihypertensive drug interactions 27 cases
(45.76% were most common at a significance level 3, 48 cases (81.36%) were onset
delayed, and the severity minor of 44 cases (74.58%). The mechanism of interactions
pharmacodynamic were 37 cases (62.71%) of the total 59 events that have drug
interactions. Drugs often interactions were furosemide and captopril.


Keywords


drug interactions; antihypertensive; hemodialysis

Full Text:

PDF


DOI: http://dx.doi.org/10.12928/pharmaciana.v2i1.658

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Siti Rahmiati, Woro Supadmi

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


 
Pharmaciana
ISSN Print: 2088-4559 | ISSN Online: 2477-0256
Website: http://journal.uad.ac.id/index.php/PHARMACIANA
Office: Faculty of  Pharmacy, Universitas Ahmad Dahlan
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia
Kode pos 55164
Email: pharmaciana@pharm.uad.ac.id