SINTESIS TURUNAN ASETOFENON DARI 1-(4-ASETOKSIFENIL-3-METOKSI)-2-PROPANIL FORMAT
Abstract
The Synthesis of acetophenone derivative from 1-(4-acetoxyphenyl-
3-methoxy)-2-propanyl formate through Fries Rearrangement in order to produce
ortho hidroxy acetophenone derivative as starting material of Flavanoid compound has
been done. The reaction of 1-(4-acetoxyphenyl-3-methoxy)-2-propanyl formate was
done by heating at 120 °C for 3 hours under AlCl3, dichloromethane as the catalyst and
solvent, respectively. The structure of the compound was identified using Infra Red
spectrometry (IR) dan GC-MS. Fries rearrangement of 1-(4-acetoxyphenil-3-
methoxy)-2-propanyl formate produce 1-(2-hyidroxy-3-methoxy-5-propenyl)-
acetophenone and 1-(2-hyidroxy-3-methoxy-5-propanyl)-acetophenone as side
product with product rendemen were 43.26% and 9.48%, respectively.
Keywords
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PDFDOI: http://dx.doi.org/10.12928/pharmaciana.v2i1.654
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