FORMULASI COLD CREAM PROPRANOLOL UNTUK PENGHANTARAN TRANSDERMAL DENGAN BASIS EMULSI YANG MENGANDUNG VCO (VIRGIN COCONUT OIL)

Muji Lestari, Annas Binarjo

Abstract


Propanolol is a non-selective beta-blocker that is used widely to overcome cardiovascular disorder.
Development of propranolol in transdermal delivery is necessary to avoid the first pass metabolism that reduces
the active metabolite up to 15-23% left. This study was objected to determine the effect of VCO (Virgin Coconut
Oil) concentration as a base and penetration enhancer of propranolol in the cold cream preparation through rat skin
membrane in vitro. Variation concentration of VCO (0%, 14%, 28%, and 42%) was added to propanolol cold
cream. Transdermal in vitro study was performed using vertical type diffusion cell with PBS pH 7,4 as receptor
media. The temperature was maintained at 35ºC with a constant stirring rate at 300 rpm. The transport was
conducted for 8 hours. Flux, efficiency, and lag time were calculated as responses. The results showed that flux at
various concentration of VCO (0%, 14%, 28%, 42%) were 12,30; 14,13; 14,52; and 23,06 -1 cm-2
respectively. The transport efficiency were 6,5x10-4; 7,5x10-4; 8,1x10-4; and 1,22x10-3 % cm-2 respectively. The
lag time were 1,13; 1,26; 1,11; and 0,92 hours respectively. It can be concluded that the VCO can be used mainly
as a base in the preparation of cold cream and can increase percutaneous permeation of propranolol significantly
(p <0.05). VCO concentration of 42% has the highest performance.


Keywords


propranolol HCl; VCO; transdermal; cold cream

Full Text:

PDF


DOI: http://dx.doi.org/10.12928/pharmaciana.v3i2.429

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Muji Lestari, Annas Binarjo

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.


 
Pharmaciana
ISSN Print: 2088-4559 | ISSN Online: 2477-0256
Website: http://journal.uad.ac.id/index.php/PHARMACIANA
Office: Faculty of  Pharmacy, Universitas Ahmad Dahlan
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia
Kode pos 55164
Email: pharmaciana@pharm.uad.ac.id