DIMETILSULFOKSID SEBAGAI ENHANCER TRANSPOR TRANSDERMAL TEOFILIN SEDIAAN GEL

Abstract

Dimethylsulfoxide (DMSO) has been intensively studied the 19th century. This
substance is used as a medicine and solve. It can also be used as an absorption
enhancer of various drugs, either synthetical or herbal medicines. This study conducted
with DMSO as transdermal absorption enhancer of theophylline, which often used as
an anti-cellulite dosage forms. The experiments studied in vitro transdermal
absorption of theophylline in gel dosage forms, containing 7% theophylline dan
various concentration of DMSO i.e. 0% , 3%, 5% and 7% DMSO respectively. These
studies used skin membrane of Wistar strain male rats in a vertical type diffusion Cell.
The results indicated that DMSO was very potential as a permeation enhancer
theophylline, the formula containing 7% DMSO increased the theophylline transport
from 17,9 µg to 139,1 µg.