Evaluasi terapi erytropoetin pada pasien hemodialisa di rumah sakit PKU Muhammadiyah Yogyakarta

Adnan Adnan, Haafizah Dania, Woro Supadmi

Abstract


Most of the patients with end-stage renal disease who undergoing hemodialysis received erythropoietin (EPO) therapy for the anemia treatment. Deficiency anemia erythropoietin is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve the anemia and can improve the quality of life of patients.

This study was conducted in an analytic observational with Cross Secsional design. The purpose of this study was to know there was a difference of red blood cell profile involve hemoglobin (Hb), Mean Corpusculair Volume (MCV), Mean Corpusculair Haemoglobin (MCH), Mean Corpusculair Haemoglobin Concentration (MCHC) and quality of life of CKD patients who received EPO and non EPO therapy in PKU Muhammadiyah Yogyakarta Hospital. Inclusion criteria in this study were PGK ICD N18.9 patients who were undergoing hemodialysis therapy at RS PKU Muhammadiyah Yogyakarta, outpatient, can read and understand the questionnaire, and accept to be a respondent.

The results of this study showed no significant difference (p>0,05) in red blood cell (Hb, MCV, MCH, MCHC) between EPO and non EPO therapy groups. The associated of EPO with the quality of life of patients in all of KDQOL domains was p> 0.05.

The conclusions of this study showed that there was no significant difference between EPO and Non EPO therapy and there was no correlation between EPO and non EPO therapy with quality of life of hemodialysis patients.


Keywords


EPO, Hb, MCH, MCV, MCHC, quality of life

Full Text:

PDF

References


Astuti, N.D., Syamsiatun, N.H., & Suryani, I., 2015, Faktor-faktor yang Berhubungan dengan Kualitas Hidup Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisa di Rumah Sakit Umum Daerah Panembahan Senopati Bantul, Jurnal Nutricia,17(1): 10-16

Bhatta S, Aryal G, Kafle RK. Journal of Pathology of Nepal (2001) Vol 1, 26 – 29. Diunduh dari URL : http://nepjol.info/index.php/JPN/article/view/4446/3716

Hanif, H.M, 2009, Edial, Resiko anemia pada penyakit ginjal kronik, diunduh dari URL: http://www.jantunghipertensi.com/ginjal/112.pdf.

Hidayati, et al..2011. Evaluasi Terapi Anemia Pada Pasien ASKES dengan Gagal Ginjal Kronis yang Menjalani Hemodialisis Rutin Di RS PKU Muhammadiyah Yogyakarta.Jurnal Manajement dan Pelayanan Farmasi, Vol.No.3 / September 2011

KDIGO, 2012, Clinical Practice Guidline for Anemia in Chronic Kidney Disease, Kidney International Suplement, 2, 279-335, Boston, MA, USA.

Keown, P.A., Churchil, D.A., Poulin-costello, M., Lei, L., Gantotti, S., Agodoa, I., Gitlin, M., Gandra, S.R., Mayne, T.J., 2010, Dialysis patient treated with epoetin alfa show improved anemia symptoms: A new analysis of the Canadian Erythropoietin Study Group trial, Hemodialysis International, 14:168-173

Mailani, F., 2015, Kualitas hidup pasien penyakit ginjal kronik yang menjalani hemodialisis: systematic review, Ners Jurnal keperawatan,11(1): 1-8

Mardyaningsih, D.P., 2014, Kualitas Hidup pada Penderita Gagal ginjal Kronik yang Menjalani terapi hemodialysis di RSUD dr. Soediran Mangun Sumarso Kabupaten Wonogiri, Skripsi, Prodi Keperawatan Stikes Kusuma Husada, Surakarta.

PERNEFRI, 2011, Konsensus Manajemen Anemia Pada Penyakit Ginjal Kronik,Perhimpunsn Nefrologi Indonesia (PERNEFRI), Jakarta.

Purwitasari, D.A., 2016, Kepatuhan Terapi Obat dan Kualitas Hidup pada Pasien Penyakit Ginjal Terminal Di RS PKU Muhammadiyah Bantul, Skripsi, Fakultas Farmasi Universitas Ahmad Dahlan, Yogyakarta.

Senduk, C.R., Palar, S., Rotty, L.W., 2016, Hubungan anemia dengan kualitas hidup pasien penyakit ginjal kronik yang sedang menjalani hemodialisis regular, Jurnal e-Clinic (eCl), 4(1): 105-110




DOI: http://dx.doi.org/10.12928/pharmaciana.v8i2.7725

Article Metrics

Abstract view : 274 times
PDF - 113 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Pharmaciana

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Pharmaciana indexed by:

Google ScholarDirectory of Open Access JournalIndonesian Scientific Journal Database (ISJD)Indonesian Publication Index (IPI)CrossrefBielefeld Academic Search Engine (BASE)Sherpa RomeoOpen Academic Journal Index (OAJI)

 

 

 

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.