Antibacterial activity of methanol extract Rhizophora mucronata leaves toward Salmonella typhi: leading the typhoid fever

Rinto Muhammad Nur, Resmila Dewi, Sutriani Kaliu

Abstract


The community has utilized Mangrove extensively, particularly as a component of traditional medicine. Rhizophora mucronata is one species that possess antibacterial, antiviral, antifungal, and insecticidal properties. According to reports, R. mucronata has antibacterial properties against the Salmonella typhi bacteria that cause typhoid fever. This research aims to obtain a methanol extract of R. mucronata leaves and assess its antibacterial potential as natural new medicine, particularly for treating typhoid fever. The extraction method is maceration with a 70 percent methanol solvent. Well, diffusion is utilized to determine antibacterial activity. Alkaloid, flavonoid, saponin, steroid, tannin, and triterpenoid are the chemical compounds identified in the methanol extract of R. mucronata leaves (MERmL). Ten percent concentration of MERmL exhibited moderate antibacterial activity (7.970.25 mm), whereas 30 percent concentration (11.380.29 mm) and 50 percent concentration (16.070.40 mm) exhibited intense antibacterial activity. Based on these findings, R. mucronata leaf methanol extracts with higher concentrations have more potent antibacterial activity against S. typhi in typhoid fever treatments.


Keywords


antibacterial; methanol extract; Rhizophora mucronata, Salmonella typhi; typhoid

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References


Amirkaveei, S. & Behrouz, A. B. (2011). Antimicrobial Effect of mangrove Extract on Escherchia coli and Penicillium digitatum. Internasional Conference On Food Engineering and Biotechnology IPCBEE, 9, 185-188.

Cseke, L. J., Ara, K., Peter, B. K., Sara, W., James, A. D., & Harry, L. B. (2006). Natural Products from Plants. Second Edition. USA, Taylor & Francis Group, LLC.

David, W. W., & Stout, R. (1971). Disc Plate Method of Microbiological Antibiotic Essay. American Society for Microbiology. 22(4), 659-665.

Dewoto, H. R. (2007). Pengembangan Obat Tradisional Indonesia Menjadi Fitofarmaka. Majalah Kedokteran Indonesia, 57(7), 205-211.

Feliatra. (2002). Sebaran Bakteri Escherichia coli di Perairan Muara Sungai Bantan Tengah Bengkalis Riau. Jurnal Biogen, 1(4), 178-181

Harborne, J. B. (1987). Metode Fitokimia: Penuntun Cara Modern Menganalisis Tumbuhan. Bandung, ITB.

Herawati, M. H. & Lannywati, G. (2009). Hubungan Faktor Determinan dengan Kejadian Tifoid Di Indonesia Tahun 2007. Media Penelitian dan Pengembangan Kesehatan, 19(4), 165–173.

Joel, E. L., & Valentin, B. (2010). Isolation and Characterization of Secondary Metabolites from The Mangrove Plant Rhizophora mucronata. Asian Pacific Journal of Tropical Medicine, 3(8), 602-604.

Kelman, D., Benayahu, Y., & Kashman, Y. (2000). Variation in secondary metabolite concentrations in yellow and grey morphs of the red sea soft coral Parerythropodium fulvum fulvum : possible ecological implication. Journal of Chemical Ecology, 26(5), 1123-1134.

Kordi, G. H. 2012. Ekosistem Mangrove: Potensi, Fungsi, dan Pengelolaan. Jakarta, Rineka Cipta.

Kusuma, S., Anil, K., & Kamala, B. (2011). Potent Antimicrobial Activity of Rhizophora mucronata. Journal of Ecobiotecnology, 3(11), 40-41.

Moorthy, K., Kesavan, S., Subramanian, C., Palaniswamy, M., & Mohanasundari, C. (2007). Phytochemical screening ang antibacterial evaluation of stem bark of Mallotus philippinensis var. Tomentosus. African Journal of Biotechnology, 6(13), 1521-1523.

Noor, Y. R., Muhammad, K., & Nyoman. N. S. (2006). Panduan Pengenalan Mangrove di Indonesia. Indonesia, National Government Publication.

Nurdiani, R., Muhammad, F., & Asep, A. P. (2012). Phytochemical screening and antibacterial activity of methanol extract of manggrove plant (Rhizophora mucronata) from Porong River Estuary. Journal Basic Science and Technology, 1(2), 27-29.

Pimpliskar, M. R., Jadhav, R. N., & Jadhav, B. L. (2011). Study on Antimicrobial Principles of Rhizophora Species Along Mumbai Coast. Journal Aqua Biol, 26(1), 6-11.

Purnobasuki, H. (2004). Prospect of Mangrove as Herbal Medicine. Biota, 9(2), 125-126.

Puspitasar, Y. E., Aniek, M. H., & Eddy, S. (2012). The Potency of Rhizophora mucronata Leaf Extract as Antidiarrhea. Journal of Applied Science Research, 8(2), 1180-1185.

Rante, H., Rosani, T., & Sri, H. N. (2016). Aktivitas Antibakteri Ekstrak Terpurifikasi Parsial Mangrove (Rhizophora mucronata Lamk). Journal of Pharmaceutical and Medicinal Science, 1(2), 17-20.

Sidabutar, S. & Hindra, I. S. (2010). Pilihan Terapi empiris Demam Tifoid pada Anak: Kloramfenikol atau Seftriakson?. Sari Pediatri, 11(6), 434-439.

Tarman, K., Sri, P., & Anak, A. A P. P. N. (2013). Aktivitas Antibakteri Ekstrak Daun Bakau Hitam (Rhizophora mucronata) terhadap Bakteri Penyebab Diare. Jurnal Pengolahan Hasil Perikanan Indonesia, 16(3), 249-258.

Widoyono. (2008). Penyakit Tropis Epidemilogi, Penularan, dan Pencegahan dan Pemberantasan. Jakarta, Erlangga.




DOI: http://dx.doi.org/10.12928/pharmaciana.v12i3.22475

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Pharmaciana
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