AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA

Didik Yuni Prasetya, Sapto Yuliani

Abstract


Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown to
reduce oxidative damage and memory deficits associated with aging. The aim of the research
was to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memory
function on Wistar rats induced by trimethyltin. The research design was post test only
controlled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I
(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)
were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma
xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.
Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groups
were given trimethyltin intraperitoneally except group I. Data indicating memory function were
obtained from radial maze test and passive avoidance test. Radial maze test data were analyzed
by ANOVA followed by LSD test, while the passive avoidance test data were analyzed with the
Kruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract of
temulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBW
and 480 mg/kgBW can prevent memory function decline on Wistar rats induced by
trimethyltin.


Keywords


Curcuma xanthorrhiza Roxb.; memory; radial maze; passive avoidance

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DOI: http://dx.doi.org/10.12928/pharmaciana.v4i2.1573

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