PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA

Hardi Astuti Witasari, Rizaldy Taslim Pinzon, Erna Kristin

Abstract


The secondary prevention of ischemic stroke can be implemented by giving aspirin.
However, some cases of aspirin resistance have been found. The purpose of this study was to
examine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic stroke
patients at Bethesda Hospital Yogyakarta. This study was using a nested case-control study
design. The Cases group was subjects who resistance to aspirin therapy. The control group was
subjects who response to aspirin therapy. The factors that affect the incidence of aspirin
resistance were analyzed by bivariate analysis chi square test. The proportion of diabetes
mellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was
1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at Bethesda
Hospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirin
resistance than the patients without diabetes mellitus.


Keywords


Ischemic stroke; aspirin resistance; diabetes mellitus

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DOI: http://dx.doi.org/10.12928/pharmaciana.v4i2.1572

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