SINTESIS SENYAWA N-(2-NITROBENZIL)-1,10 FENANTROLINIUM KLORIDA DARI 2-NITROBENZIL KLORIDA DAN 1,10-FENANTROLIN MONOHIDRAT

Artie Noor Pratiwi, Nurkhasanah Mahfudh

Abstract


The compound N-(2-nitrobenzyl)-1,10-phenantrolinium chloride has been synthesized by
nucleophilic substitution reaction bimolecular (SN2) between the 2-nitrobenzyl chloride with
1,10-fenantrolin monohydrate. This study is an experimental research of Organic Synthesis.
Synthesis is done by varying the compound 2-nitrobenzyl chloride to 1.10 Phenantroline
monohydrate ie 1:1, 3:1, 5:1 and 7:1. The purity of the compounds synthesized are determined
based on the melting range data and TLC. Identification of the structure of the compounds
synthesized done by spectrometry UV/Visible, IR and GC-MS. The results of this research is a
colorless amorphous solid from N-(2-nitrobenzyl)-1,10-phenantrolinium chloride with an
optimal yield 37%+5% and the variation of mole 2-nitrobenzyl chloride effect on the amount of
yield product, there is an optimal yield in the mole ratio of 1:1.


Keywords


Organic Syntesis Organik; 1,10-phenantroline; antimalarial; 2-nitrobenzyl chloride

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DOI: http://dx.doi.org/10.12928/pharmaciana.v4i2.1563

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