Quercetin And Curcumin Prevent Decreasing Of LDL-Cholesterol And Increasing Of HDL-Cholesterol In High Fat Diet Rats

Made Harumi P, Gita Trisna, Nyoman Odiyana P G, Deby Aulia R, Putri Khrisnawati, Arta Farmawati

Abstract


Cardiovascular disease is number one killer disease in the world. The most common etiology is atherosclerosis. LDL and HDL-cholesterol are often associated with atherosclerosis which are affected by diet. Quercetin and curcumin considered have influenced to LDL and HDL. They are antioxidant that protect against LDL oxidation and raised HDL-cholesterol. In this study, we invest about comparison effect of prevention in LDL and HDL level change, after giving quercetin and curcumin. 20 males Rattus novergicus rats in 200-300 grams divided into 4 groups. Group B, C, D were given high-fat diet for 4 weeks, while group A (negative control) was given standard woof. Group B was positive control and no treatment, C was given quercetin, D was given curcumin. The treatment and giving high-fat diet was done simultaneously to detect prevention effect. HDL and LDL-cholesterol evaluated two times, pre and post-treatment. Result showed the increase prevention level of LDL-cholesterol and decrease prevention level of HDL-cholesterol in group C and D significantly. The best prevention effect is quercetin, p=0.000. Furthermore, we showed there was no significant correlation between DLDL and DHDL-cholesterol level. In conclusion, quercetin and curcumin have a good effect in preventing hypercholesterolemia, however quercetin have better effect than curcumin.

 

Keywords: quercetin curcumin, HDL-cholesterol, LDL-cholesterol

 


Full Text:

PDF

References


Anand P, et al., 2007, Bioavailability of Curcumin: Problems and Promises, Mol. Pharmaceutics, 4 (6), 807-818.

Fernandes MM, et al., 2012, Physical exercise and microRNAs: new frontiers in heart failure, Arq Bras Car, 98(5):459–466.

Guerrero JA, et al., 2005, Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor, J Thromb Haemost, 3: 369–376.

Kaur G and Meena C., 2012, Amelioration of Obesity, Glucose Intolerance, and Oxidative Stress in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats by Combination Consisting of Curcumin with Piperine and Quercetin, ISRN Pharmacology, 2012:1-7.

Knekt P, et al., 1995, Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Study, Arch Intern Med, 155: 381–386.

Kumar V, et al., 2010, Robbin and Cotran Pathology Basic of Disease, 8th ed, Philadhelpia: Saunders Elsevier.

Miller A., 1996, Antioxidant Flavonoids: Structure, Function and Clinical Usage, Alt Med Rev, 1(2):103-111.

Moghaddam G, et al., 2012, Antiproliferative Activity of Flavonoids: Influence of the Sequential Methoxylation State of the Flavonoid Structure, Phyto Res, 26(17):1023-1028.

Naderi GA, et al., 2003, Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation, Mol Cell Biochem, 246(1–2):193–196.

Silbernagel G, et al., 2013, High-density lipoprotein cholesterol, coronary artery disease, and cardiovascular mortality, Eur Heart J, http://eurheartj.oxfordjournals org/content/early/2013/09/07/eurheartj.eht343 was accessed on December 2, 2014.

Srinivasan K, Sambaiah K, Chandrasekhara N., 2004, Spices as beneficial hypolipidemic food adjuncts: a review, Food Rev Int, 20: 187–220.

Sudjarwo, SA., 2011, Mechanisms of endothelial cell protection by quercetin in hypercholesterolemia, J App Phar Sci, 3:123–127.

Wang L, et al., 2012, Protective Effect of Polyphenol Extract of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on Hypercholesterolemia- induced Oxidative Stress in Rats, Molecules, 17: 8886-8897.

Warnholtz, A et al., 2001, Antioxidants and endothelial dysfunction in hyperlipidemia, Curr Hypertens Rep, 3:53-60.

World Health Organization., 2008, Cardiovascular Disease: Global Atlas on Cardiovascular Disease Prevention and Control, Geneva, Switzerland: WHO, http://www.who.int/mediacentre/factsheets/fs317/en/ was accessed on December 6, 2014

Yao S, et al., 2012, Quercetin protects macrophages from oxidized low-density lipoproteininduced apoptosis by inhibiting the endoplasmic reticulum stress-C/EBP homologous protein pathway, Exp Biol Med, 237(7):822–831




DOI: http://dx.doi.org/10.12928/mf.v12i2.3788

Article Metrics

Abstract view : 208 times
PDF - 246 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 Universitas Ahmad Dahlan

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


Media Farmasi
p-ISSN 1412-7946 | e-ISSN 2503-5223
Published by Universitas Ahmad Dahlan Yogyakarta Indonesia


This work is licensed under a Creative Commons Attribution 4.0 International License.


View Media Farmasi Stats